The Clinical Observation Of Protrusion Of Lumbar Intervertebral Disc By Acupuncture Combined With Acupoint-injection Of Ossotide Injection And The Effects On Concentration Of Plasma β-EP,CGRP

PURPOSECompare the result treating protrusion of lumbar intervertebral disc with two treatment.These two treatment include the treatment of acupuncture combined with acupoint-injection of Ossotide injection and the treatment of simple acupuncture;Observe the effects Of acupuncture combined with acupoint-injection of Ossotide injection on concentration Of Plasmaβ-EP,CGRP,and discuss the mechanism of the treatment on lumbar disc herniation.METHOD64 cases of protrusion of lumbar intervertebral disc were selected with certain diagnostic standard.These patients were all single or double intervertebral disc protrusion which between the fourth and fifth lumbar vertebrae or between the fifth lumbar vertebrae and the first sacral vertebrae,moreover,all the patients selected had symptoms of acute lumbago and scelalgia(short-form mcgill pain questionnaire,PPI≥2).They were randomly divided into two groups:the group of acupuncture combined with acupoint-injection of Ossotide injection (Therapy group)and another of simple acupuncture(Control group);There were 32 cases in each group.The two groups applied the same points and the same method of the needling.The points were dachangshu(EX-B2,double sides),guanyuanshu(EX-B2,double sides),Zhibian(BL54,sick side),Yanglinquan(GB34,sick side),Weizhong(BL40,double side). Therapy group:After the acupuncture and when we applied the acupoint-injection,we drawed 1ml Ossotide injection.Then we inserted into the double guanyuanshu Points of the fifth lumbar Vertebrae of the Patient and inject 0.5ml injections slowly in each Point.Control group:The Patients were needled the same Points and the same method as therapy group but had no acupoint-injection.The patients of two groups were all treated once a day,and 10 times constituted a course of treatment.They had taken a rest of three days between courses. Before the first treatment and on the first day after 2 courses of treatment,we evaluated respectively the clinic symptoms of two groups with "clinicalcurative effect judge standard", "Lower Back Pain Assessment Standard"(JOA evaluation sheet),"short-form mcgill pain questionnaire",then determinate the content change of blood plasmaβ-EP and CGRP in patients and analyse the result.RESULT(1)Observation of the curative effect:Atday 10,the total effective rate in therapy group was 83.9%and the control group was82.8%;Atday20,the total effective rate in therapy group was 90.3%and control group was86.2%.Two groups have good efficacy in the treatment of LIDP,but there was no significant difference between the clinical efficacy rates of the two groups Atday10 or day20(P＞0.05).(2) After treatment of 2 courses,JOA scores were all increased in both two groups,There was significant difference between increasing degree of JOA scores of therapy group and control group(P＜0.05).The increasing tendency of JOA scores in therapy group were higher than that of control group.After treatment of 2 courses, pain scores were all descended in both two groups,There was significant difference between falling degree of pain scores of therapy group and control group(P＜0.05).The falling tendency of pain scores in therapy group were higher than that of control group.(3)The change of the concentration of Plasmaβ-EP between pre-treatment and post- treatment: after treatment of 2 courses,the concentration of Plasmaβ-EP were all increased in both two groups and the change of it in therapy group is greater than in control group.The change of the concentration of Plasma CGRP between pre-treatment and post- treatment:after treatment of 2 courses,the concentration of Plasma CGRP were all descended in both two groups and the change of it has no significant difference in two groups.CONCLUSION(1)Both acupuncture combined with acupoint injection of Ossotide injection and simple acupuncture could ameliorate the symptom,especially in pain relief,and the effect of therapy group was superior to control group significantly.(2) Pain relieves in lumbar intervertebral disc protrusion patients is related to the change of the concentration of Plasmaβ-EP and CGRP.The increasing tendency of the concentration of Plasmaβ-EP was positive correlation with pain alleviation.The falling tendency of the concentration of Plasma CGRP was positive correlation with pain alleviation.