| BackgroundCongestive heart failure is very common in clinical heart disease led to a variety of cardiac dysfunction syndrome,cardiovascular disease,the majority of the final destination,but also the most important cause of death. Despite the continuing technical progress in medical clinics,the incidence of heart failure but have increased year-on-year trend.Contemporary physiological and pathological mechanisms of heart failure the deepening of studies have found that neuro-endocrine system of long-term cytokines,chronic activation of the promotion of cardiac remodeling and increase the myocardial damage and functional changes occurred in the basic mechanisms of heart failure.Therefore,the key to the modern treatment of heart failure is related to the neuroendocrine system to block and prevent cardiac remodeling in order to delay the development of heart failure.In recent years,the renin-angiotensin-aldosterone system(RAAS) in heart failure of the physiological and pathological mechanisms have become established.Therefore,the use of Western medicine treatment of angiotensin-converting enzyme inhibitors,such as the treatment of heart failure,in 1987 the application of angiotensin-converting enzyme inhibitor (ACEI) treatment of heart failure clinical trials,but also laid the AAS system, the basis of inhibitor treatment of heart failure.Traditional Chinese medicine,heart failure,mainly heart disease, standard virtual reality-based card,the virtual to qi deficiency,yang deficiency mainly standard is to blood,phlegm most.The virtual(Heart Yang Deficiency gas) is the key to the pathogenesis of heart failure,heart attack is the initial factors and the pathology throughout the course of heart failure, but the main reason leading to edema.Therefore,most doctors believe is Yang Qi Deficiency Syndrome Differentiation of Heart Failure Program,and the treatment of the use of the treatment Onyang Yiqi.China's well-known Professor Yan Dexin old Chinese medicine in the long-term treatment of heart failure in clinical practice,that is the key to Yang for all their lives,to be shared is that the poor too;heart precursors and with Yin-Yang,Qi Yang Heart failure is decline of cardiac function;heart failure based on the virtual card is marked,and its key point of pathogenesis gas Heart Yang,"there is a yang,it is a life." Professor Yan Dexin developed in clinical treatment of heart failure Onyang side and capsules made by large-scale clinical trials confirm that Onyang patients can be significantly improved heart failure symptoms and heart function,but have not been able to clear its specific mechanism of action.ObjectiveOnyang side analysis Yang intervention in patients with heart failure before symptoms of traditional Chinese medicine,tongue,pulse and the RAAS system in patients with pre-intervention indicators and analysis of Onyang party intervention in patients with heart failure after heart Yang of Chinese medicine in patients with symptoms,tongue,pulse and RAAS system changes in indicators to observe the clinical efficacy Onyang side,try to find the treatment of heart failure Onyang side mechanisms and the role of possible targets.MethodsSelected in accordance with the standard heart failure patients with 70 cases of Yang,single-blind randomized into the treatment of the principle of the control group(Western medicine therapy + Onyang side capsules) and control group(Western medicine therapy),in which the treatment group was given capsules Onyang side,each 3,3 times a day,continued to take 1 month. MAIN OUTCOME MEASURES for the before and after the cardiac function,heart failure score,traditional Chinese medicine symptoms,tongue,pulse and RAAS system indicators:renin(PRA),angiotensinⅡ(AngⅡ),aldosterone(ALD). Blood,urine,stool routine,liver and kidney function,blood gas analysis, blood biochemistry and chest X-ray,EKG,BNP and other indicators as a security.The results 1.In this study,70 cases into the case,five cases of loss of cases, the final treatment group received 33 cases and 32 cases of control group, two groups of patients admitted to the clinical data in general no significant differences in contrast,the cardiac function,heart failure score, classification of traditional Chinese medicine symptoms no significant difference(P＞0.05) comparable with the group;2.Treatment group and control group after treatment compared to treatment group renin(PRA),angiotensinⅡ(AngⅡ),aldosterone(ALD) levels were significantly decreased compared with the control group(P＜0.05),prompted Onyang capsule to be effective Yang regulate heart failure patients with cardiac RAAS system endocrine factor,with statistical significance;3.The treatment of heart failure after two hours of efficacy,compared with a statistically significant difference(P＜0.05),the total effective rate in treatment group was superior to the control group;the two groups after treatment compared to effect cardiac function,the difference statistically significance,treatment group was significantly higher efficiency;4.Two groups of Chinese medicine treatment efficacy compared to symptom score,the difference was significant statistical significance(P＜0.05),plus tips Onyang capsules side treatment group was significantly higher than the total effective rate.Conclusion of the studyIn this study,capsule side through Onyang Yang type of heart failure in patients with cardiac intervention effects observed in patients with heart failure prompted the use of Yang-based traditional Chinese and western medicine(TCM therapy capsules + Onyang side) can more effectively improve the patient's heart function and heart failure symptoms,as well as in patients with heart failure to reduce points,thereby enhancing the quality of life of patients.Onyang side capsule can be significantly reduced in patients with heart failure Yang RASS system type renin,angiotensinⅡ,aldosterone levels in patients with its role in the regulation of RAAS system,suggesting that Onyang side is the possibility of capsule in the treatment of heart failure mechanisms and the role of target.According to safety tips Onyang capsule has a good side of safety,no significant or serious adverse reactions. |
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