| Objective To compare the significance of the application of two definitions for metabolic syndrome(MS) proposed by the Chinese Diabetes Society(CDS) in 2004 and the one proposed by the International Diabetes Federation(IDF) in 2005. And to assess a 2-yr change in the prevalence of MS defined by CDS and IDF.Methods The data of routine clinical examination were collected from subjects who received annual oral glucose tolerance test(OGTT) for diabetes screeningin a community of Beijing in 2006 and 2008.All subjects were interviewed using prepared standard questionnaire,and received 75g oral glucose tolerance test (OGTT).Plasma glucose,insulin,lipid profile,blood uric acid,creatinine,as well as height,weight,waist circumference,blood pressure,body mass index were determined.The criteria of International Diabetes Federation(IDF) in 2005 and the China Diebetes Society(CDS) in 2004 were applied for diagnosis.Data were collected by a specialized person and analyzed with SPSS 13.0 software.Results①Using the CDS definition,the unadjusted prevalence of MS was 12.1% (men 13.6%;women7.1%) and the age-adjusted prevalence was 15.4%(men 15.4 %;women 10.6%).In comparison,the unadjusted and age-adjusted prevalence of MS defined according to IDF criteria werel 4.7%(men 15.9%;women 10.4%)and 16.9%(men 18.5%;womenl 3.9%).②The two definitions similarly classified 89.3%of the subjects as having or not having the metabolic syndrome.4.8%of the subjects had MS only under the CDS definition,while 6.5%of the subjects had MS under the IDF definition.③The prevalence of hyperglycemia and obesity as defined by CDS definition were 1.18 and 1.58 times higher than those defined by IDF definition(10.3%vs 8.7%,48.4%vs 30.7%respectively),while the prevalence rate of hypertension and low HDL cholesterol concentration as defined by IDF definition were 1.85 and 1.20 times higher than those defined by CDS definition(43.4%vs 23.5%,5.5%vs 4.6%respectively).④Using the CDS definition,The prevalence of insulin resistance was61.5%in MS,42.2%in obesity,57.8%in diabetes,55.3%in impaired glucose regulation,54.4%in hypertriglyceridemia,70.4%in low HDL cholesterol concentration and 40.1%in hypertension.Using the IDF definition,The prevalence of insulin resistance was62.8%in MS,52.5%in obesity,62.7%in hyperglycemia,64.6%in low HDL cholesterol concentration and 36.2%in hypertension.⑤In both surveys, MS was more common among men than women.In men the prevalence of MS tended to increase significantly between 2006 and 2008,from 10.1-13.6%based on the CDS definition,and from 9.4-15.4%based on the IDF definition(P＜0.05). In women the prevalence of the metabolic syndrome increased slightly from 5.4-7.1%based on theCDS definition and from 8.1-9.1%based on the IDF definition(P＞0.05).Of MS components,significant increased in the prevalences of obesity,hypertension,and dyslipidemia occurred among men,particularly obesity.Increase in the prevalences of hypertension was significant among women.In both sexes,changes in hyperglycemia were not statistically significant.Conclusions Using the CDS and IDF definition,the prevalence of MS is very high in a community of Beijing.Both definitions for MS can reflect the clustering degree of risk factors of cerebrovascular and cardiovascular diseases.The CDS definition of MS can better reflect the characteristics of obesity and hyperglycemia than the definition proposed by IDF,while the CDS definition of MS can early reflect the degree of hypertension and low HDL cholesterol concentration.Insulin resistance was common in MS and its components.Using two definition,the increase in the prevalence of MS was significant only among men between 2006 and 2008. Objective To study the outcomes and its influencing factors of the metabolic syndrome individuals in a community of Beijing.Methods Subjects who were received annual oral glucose tolerance test(OGTT) for diabetes screening in 2006 were re-investigated in 2008.The data were calculated to analyze outcomes and influencing factors of MS.All subjects were interviewed using prepared standard questionnaire,and received 75g oral glucose tolerance test(OGTT).Plasma glucose,insulin,lipid profile,blood uric acid,creatinine,as well as height,weight, waist circumference,blood pressure,body mass index were determined.MS and its related risk factors were determined according to CDS criteria(2004).Data were collected by a specialized person and analyzed with SPSS 13.0 software.Results①1022 subjects received OGTT for diabetes screening at baseline, among whom 618 were investigated again two years later.The prevalence of MS, DM,IGR,hypertension,abnormalities in BMI,abnormalities in WC, dyslipidemia at baseline were 10.0%,2.8%,6.4%,18.8%,43.9%,19.9%,29.1%, and that werel 7.0%,3.9%,7.4%,29.0%,52.3%,33.3%,40.5%,respectively when followed up.②In MS group,the 2hPG,TC,TG,SBP,UA,HDL-C were significantly decreased,and the FINS and HOMA-IR were increased in two years' time.In non-MS group,the WC,LDL-C,FINS,2hINS,HOMA-IR were significantly increased,and the HDL-C were decreased.③The conversion from MS to non-MS was 13.1%,and from non-MS to MS was 9.3%;The conversion from IGR to DM and NGT were 17.9 and 48.7%,respectively;The conversion from NGT to IGR was 5.9%.④In MS→non-MS group,the BMI,2hPG,2hINS,TC,TG,HDL-C,LDL-C,SBP,DBP,UA was decreased,and change of DBP was statistically significantly(P＜0.05);while in non-MS→MS group,the WC,2hPG,FINS,2hiNS,SBP,DBP were significantly increased(P＜0.05),and HDL-C was significantly decreased(P＜0.05).⑤In MS→non-MS group,improved degree of BMI,2hINS,TG,LDL-C and SBP in two years' time more significant than in the maintenance of MS(P＜0.05).In non-MS→MS group,aggravated degree of WC,2hPG,FINS,2hINS,HOMA-IR,LDL-C,SBP and DBP in two years' time more significant than in the maintenance of non-MS(P＜0.05 ).⑥The stepwise Logistic regression analysis showed that the FPG and DBP at baseline were positively correlated,and the HDL-C at baseline was negatively correlated with the conversion from non-MS to MS.Conclusions The prevalence of MS and its related disease in two years' time were increased in the community of Beijing. The conversion from non-DM to DM and from non-MS to MS were very high.In MS subjects,some metabolic indicator occured obvious improvement.The improved degree of BMI,2hINS,TG,LDL-C and SBP were the influencing factors of the conversion from MS to non-MS and the maintenance of MS;The aggravated degree of WC,2hPG,FINS,2hINS,HOMA-IR,LDL-C,SBP and DBP were the influencing factors of the conversion from non-MS to MS and the maintenance of non-MS.The FPG and DBP at baseline were positively correlated, and the HDL-C at baseline was negatively correlated with the conversion from non-MS to MS. |
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