Changes Of Platelet Activating Factor In Kawasaki Disease And Its Clinical Significance

Objective:Through detecting the plasma levels of platelet activating factor (PAF), polymorphonuclear neutrophil (PMN) counts and platelet (PLT) counts in acute stage and convalescence of Kawasaki disease, to explore relationship between PAF and Kawasaki disease, and to further explore the pathogenesis of Kawasaki disease.Methods:Kawasaki disease group: Forty in-patient children with Kawasaki disease were collected in heart medical department of Shan xi province children's hospital from April 2008 to September 2008, including 27 boys and 13 girls. According to 2D-echocardiogram, this group was divided into coronary artery lesion group (16 cases) and non-coronary artery lesion group (24 cases). Control group: Twenty children with normal physical examination were enrolled as control group, including 12 boys and 8 girls. To draw venous blood of normal children and Kawasaki disease group in acute stage and convalescence. Plasma levels of PAF were measured by enzyme linked immunosorbent assay. PLT and PMN counts were measured by automatic cytoanalyzer.Results:1. Plasma levels of PAF in acute phase and convalescent phase of Kawasaki disease were higher than that in control group, both had statistical difference(P<0.05); Plasma levels of PAF in acute phase were higher than convalescent phase (P<0.05). PLT counts in acute phase and convalescent phase of Kawasaki disease were higher than that in control group, both had statistical difference (P<0.05); PLT counts in acute phase were higher than convalescent phase (P<0.05).PMN counts in acute phase of KD were higher than that in convalescent phase and control group, both had statistical difference (P<0.05); there was not significant difference between that in convalescent phase and control group (P>0.05).2. In acute phase of Kawasaki disease, plasma PAF and PLT in patients with coronary artery lesion group were higher than that in non-coronary artery lesion group, both had statistical difference (P<0.05). Compared with non-coronary artery lesion group in acute stage, coronary artery lesion group had not significant difference in PMN (P>0.05). There were not statistical difference between coronary artery lesion group and non-coronary artery lesion group in convalescence phase (P>0.05).3. PAF and PLT were positively related with coronary artery lesion in acute phase of Kawasaki disease (P<0.01). PAF were positively correlated with both PLT and PMN (P<0.01).Conclusions:PAF might take part in the pathogenesis of Kawasaki disease through interaction with PLT and PMN. Besides, PAF was associated with coronary arterial lesion.