Study On Changes Of Serum CRP Level In Patients With Atherosclerotic Cerebral Infarction

Objective To study the changes of serum Hs-CRP level in patients with acute cerebral infarction.Methods(1) All 259 ACI patients were classified into 5 major ischemic stroke subtypes based on TOAST and improved TOAST criteria,the serum Hs-CRP was measured in all patients,and then the relationship between Hs-CRP level and their subtypes were analyzed.(2) All 151 patients were divided into four groups according to the results of MRI examination,the serum Hs-CRP was measured,all the patients were scored by NIH stroke scale,and followed up by 16 months in 117 patients.Results(1) The percentage of each ischemic stroke TOAST subtypes of 259 patients was as following:stroke of large-artery atherosclerosis 39.4%,small-artery disease 30.9%,stroke of undetermined etiology 23.9%.While in improved TOAST subtypes, compared with large-artery atheroselerosis,the percentage of Atherothrombosis elevated to 58.3%.Among all ischemic stroke subtypes,cardioembolism patients were related to the highest Hs-CRP level[(13.19±8.70)mg/L,(14.31±9.49) mg/L].The Hs-CRP level and positive rate in Small-artery di sease patients were lowest.(2)Serum Hs-CRP level was significantly higher in the group of artery to artery cerebral embolism and embolus eliminating disorder than atherosclerotic perforating branches occlusion (P＜0.05);In artery to artery cerebral embolism group,Hs-CRP of the patients with smoking,past stroke,hypertension,angiostenosis were higher than those without that; The more severe of neurologic impairment,the higher of Hs-CRP,Mutiple Logistic Regression analysis revealed that the value of NIHSS1 was associated with Hs-CRP level; Different degree of angiostenosis had different recurrent rate,the ratio of angiostenosis was positive correlation with stroke recurrence,an independent risk factor for rupture-prone plaque.Conclusions(1)Improved TOAST criteria can reduce the percentage of undetermined etiology.Hs-CRP level varied with different subtypes of ACI.The Hs-CRP may play a role in ACI development and be tested as a typing index.(2) The level of serum Hs-CRP is associated with stability of atherosclerotic plaque,and it supplied an quantitate information for neurologic impairment.