The Effect Of Gastric Motility On Patients With Functional Dyspepsia Induced By Sleep Disorder

Research indicates that patients with functional dyspepsia usually havechange of emotion and psych-stress. At present, etiopathogenesis research offunctional dyspepsia doesn't only lie in gastrointestinal tract, role of centralnervous system in functional dyspepsia's pathogenesy is paid closer attentiongradually. Functional disorder of central nervous system is an importantinfluential factor to many functional diseases. Many epidemiologicinvestigations discover that functional dyspepsia is mostly accompanied withbreakdown of sleep quality and sleep disorder. The influence of sleep disorder togastrointestinal tract motivation is not still identified, furthermore, research ofcorrelated mechanism of action is yet reported. So we analysis sleep features ofthe patients who have sleep disorder and functional dyspepsia, we study changesof gastro-myoelectricity and motilin, somatostatin in blood plasm of thosepatients. Finally, we approach effect and correlated mechanism ofgastrointestinal tract motivation induced to sleep disorder, which will providestheory base to clinic treat.Objectives: To approach effect and correlated mechanism of gastrointestinaltract motivation induced to sleep disorder, to provide theory base to clinic treat.Methods: Sleep disorder (according to Pittsburgh sleep quality index and polysomnogram), functional dyspepsia ( according to Romeâ…¢criteria). Casesare patients in out-patient clinic and hospitalization from October 2007 to March2008(n=34). Group A: 26 patients of sleep disorder and functional dyspepsia.According to International Classification of Sleep Disorder in 2005(ICSD-â…¡),there are three sub-groups: Group AI: 14 patients of insomnia with functionaldyspepsia; Group AII:8 patients of sleep disorder pertinent to anapnea withfunctional dyspepsia; Group AIII: 4 patients of other sleep disorder withfunctional dyspepsia. Group B: 8 patients of functional dyspepsia. Group C: 8healthy volunteers.Every experimenter was monitored whole night synchronically usingpolysomnometer and electrogastrogram recorder. Sleep parameters of everygroup were contrasted and analyzed. The changes of percentage of somnolenceS2 period's and deep sleep S4 period's gastro-myoelectricity basic frequency,bradygastria, normal slow wave, tachygastria were observed stressfully. Wegained their venous blood the next morning then we determined Motlin andSomatostatin with radio-immunity method.Results: 1. Deep sleep time and rapid eye move sleep time of Group A andGroup B are shorter than Group C(p<0.05); Whole sleep time, sleep delitescence,deep sleep ratio, rapid eye move ratio, sleep efficiency of Group A are degradecompared to Group B and Group C (p<0.05). There isn't significant differenceamong the three groups'whole record time(p>0.05). Basic frequency of S2, S4,REM and percentage of normal slow wave of Group A are decreased comparedto Group B, Group C (p<0.05), percentage of bradygastria heightened (p<0.05).2. Level of motilin and somatostatin in blood plasma: Group A>GroupB>Group C (p<0.05).3. Pittsburgh sleep quality index, superficial sleep's basic frequency and deep sleep'basic frequency, somatostatin of Group AI is hightened compared toGroup AII(p<0.05), motlin decreased(p<0.05), awakeness basic frequency,REM basic frequency, tachygastria percentage, normal slow wave percentage,bradygastria percentage of Group AI are not markedly different from these ofGroup AII(p>0.05).Conclusion: Gastro-myoelectricity's basic frequency of patients of sleepdisorder with functional dyspepsia in every sleep period is depressed, and thelevel of motilin and somatostatin is increased, which prompts sleep disorder andfunctional dyspepsia are correlated closely. The mechanism of effect of gastricmotility is possibly concerned with changes of motilin and somatostatin.