| Objective:Congested heart failure(CHF) has the development basic mechanism is ventricle restructuring,observe the clinical effect of the Jian xin granular(JXKL)on the heart function,the ventricle remould (VR) and the forward quality of life influence.In obtains the good clinical proof in the foundation,and further discusses the Jian xin granular through the animal experimentation to prevent and control the action mechanism which the big mouse early time heart failure.Methods:The clinical observation method chooses my hospital 2006 to 2007 inpatient,Altogether observes 80 examples,All case of illness conformed to《Chinese native medicine New Medicine Treatment Congested Heart failure Guiding principle》in 1995 to formulate《Congested Heart failure Diagnosis And Treatment Countermeasure》with the Chinese Cardiovascular Committee heart failure study team, In 1998 formulated《Cardiovascular Medicine Clinical test Assess -ment method Suggestion》the diagnosis standard and the heart function judgment standard and the Framingham standard drew up. Divides into the treatment group and control group each 40 examples stochastically.Two groups of sexes,the age,the course of an illness,the heart function and the foundation condition diff- erences do not have the significance significance(P＜0.05),has the commeasurability.The treatment group fades in the treatment foundation in the conventional western medicine anti-heart,adds takes with the Chinese medicine Jianxin granular;The control group only fades take the conventional western medicine anti-heart the treatment,the treatment course as half year.Observes around its treatment the heart function graduation level and the left room shoots the menstruation number,and makes statistics processing, compared with its curative effect.Around the treatment the labo -ratory inspection routine blood test,the routine urine test,the excrement convention,the hepatorenal function took the secure target,by determines the Jianxin granular whether virulent,side effect.The animal experimentation method uses clean level SD big mouse 80,body weight 300-400g,takes 12 to counterfeit stochastically the surgery group,-odd 68 are the surgery groups.The surgery group uses the abdomen aorta to shrink the narrow technique manufacture pressure excess load early time chronic heart to fade the big mouse model and divides into the model group stochastically,the western medicine group,Jianxin granular high dose and low monitoring team. After makes the mold 6 weeks separately to give sham-operation group each distilled water 1ml/100g to i.g.,the model group each only gives the 1ml/100g distilled water to i.g.,Western medicine group give Luo ding xin suspension 1ml/100gi.g.,jianxin granular high monitoring team give jianxin granular suspension 1ml /100gi.g., jian-xin granular low monitoring team give jianxin granular sus -pension 0.25ml/100gi.g.,Examination different group of big mouse blood stream dynamics and the left room large target,observe the jianxin granular influence in the blood stream dynamics and the left room large target which fades to the big mouse early time heart, and makes statistics processing,Compared with jianxin granular and Luo Ding xin effect.Result:1.In around the clinical observation treatment group and the control group two groups treats compares,May improve left room contraction function target LVEF and the heart function graduation level,has statistics significance(P＜0.01,P＜0.05).Treatment group function is more remarkable,has the significance with the control group comparison difference(P＜0.05).2.The animal experimentation jianxin granular height monitoring team and the western medicine group may improve the early heart failure big mouse's blood stream dynamics and the left room large target,has statistics significance(p＜0.01,p＜0.05).The jianxin granular high monitoring team and Luo Ding Xin compares the not remarkable difference(p＞0.05),the jianxin granular high monitoring team and the low monitoring team have the remarkable difference(p＜0.05).Conclusions:1.The jianxin granular has the accurate curative effect regarding the chronic heart failure patient,may alleviate the chronicity congested heart failure clinical symptom which each kind of foundation disease causes,also has not had the poison,the side effect.2.The jianxin granular may improve the old age chronic heart failure effectively patient's heart function,suppresses development which the ventricle restructures,reduces fades careless the symptom.3.The jianxin granular improvement early time heart failure big mouse's blood stream dynamics and the left room large target... |
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