Correlation Between Serum Lipids Concentration And Severity Of Coronary Artery Stenosis In Men

Objectives Investigating the correlation between serum lipids concentration and existence as well as severity of coronary atherosclerosis in the men with no diabetes mellitus, Cigarette smoking and family history, to help identify the predicting value of serum lipids concentration in these people and provide evidence for the prevention and therapeutics of coronary artery disease.Methods A retrospective study was conducted on 96 patients fitting the admission standards from the 842 ones who underwent their first angiography in the Intervention Center of Shandong Provincial Hospital between January and December in 2007. Fasting serum concentrations of TC,TG,HDL-C,LDL-C, Lp(a),ApoAI,ApoB, FBG,DB,TB,UA were measured, also the Age, Blood pressure and other clinical data were collected; the severity of coronary artery stenosis was evaluated by the GS. All patients were classified as control group, single-vessel group, double-vessel group and multiple-vessel group, according to the number of main coronary arteries which stenosis was more than 50% diameter; and were assigned into the following quartiles: 0-16,17-40, 41-72,and above 74, according to the GS. The correlativity between every serum lipids concentration and the extent of coronary artery stenosis were analyzed and the interaction between serum lipids and other factors were also studied to identify the their influence to the severity of coronary artery stenosis.Results TC, LDL-C and Age were significantly higher in the multiple-vessel group than in the other group, and were demonstrated to be highly significantly (P<0.001) associated with the number of stenotic coronary arteries; DB was significantly lower in the multiple-vessel group than in the other group and had a significant negative correlation with the number of stenotic coronary arteries (P=0.010); ApoB, Lp(a) had positive correlation with the number of stenotic coronary arteries(P=0.014 and 0.024, respectively), but the differences between the groups had no significance; There were no relationship between the number of stenotic coronary arteries and TG,HDL-C, ApoAI, FBG,TB,UA, Blood Pressure. TC and LDL-C had no significant difference between different GS groups, but significant positive correlation with the GS in the partial correlation analysis (P=0.036 and 0.001, respectively); The partial correlativity between Lp(a),Age and the GS had no significance, but the differences between distinct GS groups were significant, and highest value were located in 17-40 and 41-74 group respectively; Other observed factors had no significance not only in the comparison between different GS groups, but also in the partial correlation analysis with the GS. By multiple linear regression, there were significant relationships between Age, pulse pressure, FBG, HDL-C, LDL-C and GS in men. The regression equation was: GS=1.061age-0.799pulse pressure+9.401FBG-15.657HDL-C+18.992LDL-C-58.466.Conclusions There was a negative correlation for HDL-C, and positive correlations for TC, LDL-C, Lp(a), ApoB, and no significant correlation for TG, ApoAI, with the severity of coronary stenosis; The serum lipids concentration can predict the severity of coronary, especially the TC and LDL-C.