Analysis Of Correlation Between Lipids And Coronary Artery Stenosis Severity

Objective:To explore the relationship between lipids and the severity of coronary artery stenosis and to evaluate the lipids and lipid ratios in risk assessment of coronary artery disease(CAD).Methods:By retrospective analysis,a total of 511 patients undergoing coronary angiography in the Second Affiliated Hospital of Zhejiang University of Medcine from June 2015 to May 2016 were enrolled in the study.Baseline data and lipid levels were collected for each patient.According to Gensini score(GS),the patients were classified into three groups:control group(GS=0;n=85),low GS group(GS 1 to 20;n=220),high GS group(GS≥21;n=206).The relationship between lipids and lipid ratios with coronary artery stenosis was analyzed and the role of lipids in CAD risk assessment was evaluated.Results:The baseline data showed that the proportion of male,hypertension,diabetes and smoking as well as age was higher in high GS group(P<0.05);The lipid data showed that HDL-C and apoAl was lower in high GS group(P<0.05),TC,LDL-C,non-HDL-C,apoB,apoB/apoAl and non-HDL-C/HDL-C were higher in high GS group(P<0.05).Correlation analysis of lipids level and GS showed that the severity of coronary artery stenosis was negatively correlated with HDL-C and apoAl(r=-0.23 for HDL-C and r=-0.24 for apoA;both P<0.05),but positively correlated with apoB,apoB/apoAl and non-HDL-C/HDL-C(r=0.141 for apoB;r=0.224 for apoB/apoAl,r=0.219 for non-HDL-C/HDL-C;all P<0.05).Logistic stepwise regression analysis showed that apoB and apoB/apoAl were independent risk factors for coronary artery stenosis(OR=2.00 and 2.11 respectively;P<0.05)and HDL-C was a protective factor for coronary artery stenosis(OR=0.36;P<0.001)Conclusion:There is a correlation between dyslipidemia and coronary artery stenosis.The severity of coronary artery disease can be predicted by lipid levels.ApoB/apoAl is better in assessment of coronary artery stenosis.