Huatan Act Yunpi Intervention Type 2 Diabetes Insulin Resistance Spleen Dampness Certified Clinical Research

Objective: To observe the law Yunpi Huatan Decoction of type 2 diabetes insulin resistance spleen dampness clinical signs and symptoms before and after certification, Homa-IR, beta cell function ,fasting and 2 hours postprandial blood glucose, blood lipids, blood rheology , TNF-αchanges in the its clinical efficacy and safety evaluation.Methods: 60 cases of type 2 diabetes insulin resistance in patients with spleen dampness cards were randomly divided into 2 groups. 30 patients in treatment group were treated with Yunpi Huatan Decoction ,Metformin and the basic treatment, 30 patients in the control group did not take Chinese medicine. 4 weeks for one course of treatment, observation of 2 treatment. Improve the relevant checks before and after treatment. Observed in patients with clinical symptoms and signs of change, Homa-IR, beta cell function, FBG, PBG, TC, TG, LDL-C, HDL-C,biood viscosity,TNF-αchanges.Results: Yunpi Huatan Decoction could ameliorate the clinic symptoms of the patients obviously the difference was significant compared to the control group (P <0.01) .The total effective rate was 93.33% in treatment group,10 was excellent,18 was efficient,and 2 was inefficient among the total.And the total effective rate was 63.34% in control group,2 was excellent, 17 was efficient, and 11 was inefficient among the total. Meanwhile, treatment group could effectively reduce FBG, 2hPBG which showed a significant difference before and after treatment (P<0.01), and the improvement of FBG and 2hPBG has significant differrence compared to control group(P<0.05).Treatment group could improved insulin resistance and beta cell function(P<0.01).Treatment group could also improved effectively reduce TG(P<0.05) and LDL-C(P<0.01).The majority of hemorheology improved after treatment of Yunpi Huatan Decoction(P<0.05). Treatment group could effectively reduce TNF-α(P<0.01).Conclusion: Yunpi Huatan Decoction has sure curative effection on treating type 2 diabetes insulin resistance spleen dampness.It is worth studying deeply and developing further.