| Objective To evaluate the effect of edaravone on myocardial protection in patients with cardiopulmonary bypass(CPB)during on-pump beating heart surgery.Mothod Sixty patients with rheumatic heart disease undergoing mitral valve replacement were divided into two groups:experimental group(group E,n=30),patients received edaravone injection 0.5mg/kg in circuit priming fluids;control group(group C,n=30),patients received equal volume of normal saline.The blood samples were taken at six different intervals,before surgery and 30 minutes after CPB,the end of CPB,postoperation,24 hours after postoperation,72 hours after postoperation and to test the levels of SOD,CK-MB,LDH,cTnT and MDA.Results 1. The content of LDH,CK-MB and cTnT in the two groups was similar before operation(p>0.05),while those indexes of the two groups after operation were higher than before operation(P<0.05),and those indexes of group E were lower than group C at each time points after CPB(P<0.05).2. The level of MDA,SOD in the two groups was similar before operation(P >0.05),while the level of SOD decreased continuously from the time point of T2.The index of SOD increased from T4 and would reached gradually to the normal level in the two groups. The level of MDA increased continuously after T2,while it began to decrease from T4 and would reached to the normal level in the two groups.The changes of SOD and MDA in the two groups were more significant than those in group C(P<0.05). Conclusion This study suggests that edaravone injection can offer well protective effect on myocardial ischemia-reperfusion injury during open heart surgery,and confer a direct benefit to the patients by increasing the activity of SOD,decreasing the production of MDA and leaking of myocardial enzyme.
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