Initially Investigation Of Early Intervention Therapy Of The Hearing Impairment Due To Cytomegalovirus Infection In Infants

ObjectiveTo explore the change of brainstem auditory evoked potential (BAEP) and to investigate the curative effect of the early intervention therapy mainly combining with Ganciclove on the hearing impairment resulted from Cytomegalovirus (CMV) infection in infants.MethodsBAEP were performed in 45 infants with CMV infection to screen and evaluate the hearing ability, recording the early intervention therapy combining with Ganciclove, nutrition of brain cell, stimulating sense of hearing and so on. Then we observed the effect of treatment after 4-6 months follow-up.ResultAbnormal for both ears of 35 cases (77.8%), Abnormal for one ear of 10 cases (22.2%), Only mildly higher objective hearing threshold of 28 cases (62.2%), mildly higher objective hearing threshold with abnormal waves were 5 cases (11.1%), only objective hearing thresholds of moderate to severe increased were 1 case (2.2%), objective hearing threshold increased with moderate to severe with abnormal waves were 11 cases (24.4%). Not found to have normal objective hearing thresholds with the wave of cases of abnormal changes. After therapy termination and then 4～6 months later, BAEP were investigated,36 cases (87.8%) turn to normal,4 cases (9.8%) were improved, 1 cases (2.4%) showed no effect. The total effective rate was 97.6%.ConclusionCMV infection in infants can cause varying degrees of hearing impairment. The most usually performance is mild increase in objective hearing threshold. The second performance is moderate to severe increased in objective hearing threshold with the waves of abnormal changes. The third performance is moderate to severe increased in objective hearing threshold with out the waves of abnormal changes. This method is efficient and secure and it is good for clinical application.