The Expression Of Resistance Protein In Recurrent Metastatic Breast Cancer And Its Correlation With Hormone Receptors

ObjectiveTo detect the expression of BCRP and MRP-1 in recurrent metastatic breast cancer (RMBC)and non-recurrent metastatic breast cancer(NRMBC) separately, then to evaluate the correlation between them and hormone receptors.MethodsTo group the 126 invasive ductal breast cancer patients accepted modified radical mastectomy according to their recurrence and hormone receptor properties. BCRP and MRP-1 expression were detected with SABC Immunohistochemical staining in all groups, then to analyze their correlation with the ER,PR and HER2 hormone receptor.Results1. BCRP and MRP-1 are dispersed in the cytoplasm and cell wall of breast cancer with the round buffy particles. Besides, they both express in the normal para-carcinoma tissue, with lower indensity and unequal distribution.2. In NRMBC group, the expression of BCRP is positively correlated with ER(Rs=0.39,p<0.01),with significant statistics difference; the same with PR(Rs=0.26, p<0.05),although there is no correlation between BCRP and HER2. While in RMBC group,the expression of BCRP is only positively correlated with ER(Rs=0.31, p<0.05);And in all specimens, there is no relation between MRP-1 and the three hormone receptors.ConclusionsIn patienst with breast cancer, the high expression of ER indicates the same expression of BCRP, which suggests the strong resistance ability. We can use this as one of the references to choose the reasonable endocrine therapy and chemotherapy plan. While the expression of PR may be similar with ER in NRMBC group, it cannot be the reference to resistance in the RMBC group and the ones are inclining to.