Study Of The Association Between Absorbent Energy And Infant Outcomes In Overweight And Obesity Pregnant Women

Part One Study of the Association between Absorbent Energy and Infant Outcomes in Overweight and Obesity Pregnant Women0bjective:To study the change of obstetrics pregnancy complications in overweight and obesity pregnant after diet intervention and the relationship between the calorle intake and complications of pregnancy.Methods:67 overweight and obesity diet controller pregnant as study group, 63 overweight and obesity non diet controller pregnant as comparative group and 59 cases of normal pregnant weight as normal group. Control diet of study group to keep the fetal growth and weight in a best condition. To record the real calorle intake of 3 groups of pregnant after 12 weeks every month and the biparietal diameter (BPD), circumference(AC), femoral length(FL) and complications of pregnancy and obstetrics pregnancy complications of these fetuses in every pregnancy check-ups.Results: (1) The age, pregnancy weeks, pregnancy times and parity of study groups, normal groups and comparative groups had no significant difference (P>0.05).The increase of weight in study groups is significantly lower than that in comparative groups and normal groups. The difference is significant (P<0.05). (2) Gestational age of new born infant in study groups and comparative groups and normal groups had no significant difference (P>0.05).The biparietal diameter (BPD), circumference(AC), and femoral length(FL)in study group were respectively 3366.12±208.93g , 93.04±2.06cm, 307.94±12.71cm and 72.19±3.73cm;The biparietal diameter (BPD), circumference(AC), and femoral length(FL) in comparative group were respectively 3549.21±489.94g,97.80±3.45cm,331.33±15.49cm and 77.06±2.46cm;The biparietal diameter (BPD), circumference(AC), and femoral length(FL) in normal group were respectively. The weight, the biparietal diameter (BPD), circumference(AC), and femoral length(FL) in new born infant of study group is significantly less than these in comparative group. The difference (P<0.05) is obvious. (3)The rate of post-partum hemorrhage, cesarean section rate, asphyxia of newborn, gestational diabetes mellitus, decidual of preeclampsia, anaemia in pregnancy and macrosomia in study group is obviously lower than these in the comparative group.The difference (P<0.05) is significant. The rate of FGR and congenital malformations in study group and comparative had no significantly different(P>0.05).The post-partum hemorrhage, cesarean section rate, asphyxia of newborn, gestational diabetes mellitus, decidual of preeclampsia, anaemia in pregnancy, macrosomia, FGR and congenital malformations in study group and group with normal group had no significantly different(P>0.05).(4)The Carole intake in study group during early pregnancy, middle pregnancy and late pregnancy respectively are 2067.21±100.24kcal,2070.10±115.06kcal及2083.15±63.10kcal. The Carole intake in comparative group during early pregnancy, middle pregnancy and late pregnancy respectively are 2104.25±54.94kcal,2689.79±99.77kcal and 2582.68±68.66kcal.The Carole intake in group with normal weight during early pregnancy, middle pregnancy and late pregnancy respectively are 2061.19±63.29kcal,2504.56±98.26kcal and 2378.25±41.64kcal.The carole intake in study group during early pregnancy and group with normal weight had no significantly difference(P>0.05). The carole intake in study group during middle pregnancy and late pregnancy is significantly less than these in group with normal weight. The difference (P<0.001) is great. (5)The carole intake in study,comparative and normal group during early pregnancy has nothing to do with the weight, biparietal diameter (BPD), circumference(AC), and femoral length(FL) of new born infant (r=0.125,r=0.004,r=0.178,r=0.000,P>0.05). The carole intake in study,comparative and normal group during middle pregnancy positively correlated with the weight, biparietal diameter (BPD), circumference(AC),and femoral length(FL) of new born infant(r=0.475,r=0.583,r=0.602,r=0.564,P<0.05). (10) The carole intake in study,comparative and normal group during late pregnancy positively correla-ted with the weight, biparietal diameter (BPD), circumference(AC), and femoral length(FL) of new born infant(r=0.498,r=0.455,r=0.565,r=0.491,P<0.05).Conclusions: When the weekly increased weight of overweight and obesity pregnant women controlled under 0.3kg and the carole intake controlled about 2100kcal,the bad result can be reduced during pregnancy.Part two The function of the fasting blood glucose, triglyceride and cholesterol in the fetal growth and development and the study of the associationObjective: To investigate the possible roles and relationships of the cholesterol, triglyceride and fasting blood glucose on fetal growth and development.Methods: 67 overweight and obesity diet controller pregnant as study group, 63 overweight and obesity non diet controller pregnant as comparative group and 59 cases of normal pregnant weight as normal group. Control diet of study group to keep the fetal growth and weight in a best condition. Exam the standard of TC, TG and FBG in early, middle and term pregnancy, in order to investigate the possible roles and relationships of TC, TG and FBG on fetal growth and development.Results: (1) Cholesterol levels in study group during early pregnancy, middle pregnancy and late pregnancy were respectively 4.70±0.77mmol/L, 4.72±0.82mmol/L and 5.26±1.00mmol/L. Cholesterol levels in comparative group during early pregnancy, middle pregnancy and late pregnancy were respectively 4.85±0.78mmol/L, 5.27±0.85mmol/L and 5.72±0.92mmol/L. Cholesterol levels in group with normal weight during early pregnancy, middle pregnancy and late pregnancy were respectively 4.23±0.94mmol/L, 4.55±1.04mmol/L and 5.09±1.26mmol/L.Serum cholesterol levels in study group and comparative group had no significant difference (P> 0.05). Serum cholesterol levels in study group during middle and late pregnancy was significantly lower than these in comparative group. The difference was significant (P<0.001). Serum cholesterol levels in study group during early pregnancy were significantly higher than these in group with normal weight. The difference was significant (P<0.05). Serum cholesterol levels in study group and group with normal weigh during middle and late pregnancy had no significant difference (P>0.05). (2) Triglyceride levels in study group during early pregnancy, middle pregnancy and late pregnancy were respectively 2.21±0.48mmol/L, 2.41±0.68mmol/L and 2.93±0.88mmol/L. Triglyceride levels in comparative group during early pregnancy, middle pregnancy and late pregnancy were respectively 2.43±0.46mmol/L, 2.94±0.62mmol/L and 3.34±0.63mmol/L. Triglyceride levels in group with normal weight during early pregnancy, middle pregnancy and late pregnancy were respectively 1.68±0.59mmol/L, 2.27±0.84mmol/L and 2.79±1.14mmol/L. Serum triglyceride levels in study group during early pregnancy and comparative group had no significant difference (P>0.05). Serum levels in study group during middle and late pregnancy was significantly lower than these in comparative group. The difference was significant (P<0.001). Serum triglyceride levels in study group during early pregnancy were significantly higher than these in group with normal weight. The difference was significant (P<0.05). Serum triglyceride levels in study group and group with normal weigh during middle and late pregnancy had no significant difference (P>0.05). (3) Fasting glucose levels in study group during early pregnancy, middle pregnancy and late pregnancy were respectively 4.34±0.25mmol/L,4.41±0.31mmol/L and 4.51±0.41mmol/L. Fasting glucose levels in comparative group during early pregnancy, middle pregnancy and late pregnancy were respectively 4.37±0.34mmol/L, 4.92±0.73mmol/L and 5.10±0.67mmol/L. Fasting glucose levels in group with normal weight during early pregnancy, middle pregnancy and late pregnancy were respectively 4.30±0.26 mmol/L,4.48±0.34 mmol/L and 4.59±0.45 mmol/L. Fasting glucose levels in study group during early pregnancy and comparative group had no significant difference (P>0.05). Fasting glucose levels in study group during middle and late pregnancy was significantly lower than these in comparative group. The difference was significant (P <0.001). Fasting glucose levels in study group during early pregnancy were significantly higher than these in group with normal weight. The difference was significant (P<0.05). Serum triglyceride levels in study group and group with normal weigh during middle and late pregnancy had no significant difference (P>0.05). (4)In the study,comparative and normal group during early, middle and late pregnancy, the level of serum cholesterol and neonatal birth weight, biparietal diameter, abdominal circumference, femur length was positively correlated (r = 0.563, r = 0.735, r = 0.585, r = 0.646, P<0.001 )(r = 0.562, r = 0.749, r = 0.585, r = 0.646, P<0.001 )(r = 0.567, r = 0.674, r = 0.569, r = 0.211, P<0.001 ). (5) In the study,comparative and normal group during early, middle and late pregnancy, the level of serum triglyceride and neonatal birth weight, biparietal diameter, abdominal circumference, femur length was positively correlated (r = 0.522, r = 0.800, r = 0.628, r = 0.711, P<0.001) (r = 0.557, r = 0.758, r = 0.611, r = 0.679, P<0.001). (r = 0.486, r = 0.636, r = 0.531, r = 0.601, P<0.001). (6)In the study,comparative and normal group during early pregnancy, the level of fasting glucose and neonatal birth weight, biparietal diameter, abdominal circumference, femur length was no significant correlated (r =- 0.074, r = 0.022, r =-0.050, r =- 0.053, P> 0.05).In the study,comparative and normal group during middle pregnancy, the level of fasting glucose and neonatal birth weight, biparietal diameter, abdominal circumference, femur length was positively correlated (r = 0.231, r = 0.616, r = 0.443, r = 0.438, P< 0.001).In the study,comparative and normal group during late pregnancy, the level of fasting glucose and neonatal birth weight, biparietal diameter, abdominal circumference, femur length was positively correlated (r = 0.382, r = 0.684, r = 0.583, r = 0.546, P<0.001).Conclusion: Pre-pregnancy overweight and obese pregnant women accumulate fat and they can increase the movement of fat to promote the growth of infant. The overweight and obese pregnant women need the carole intake controlled about 2100kcal, which can reduce the risk of metabolic diseases after their adulthood.