The Influence Of Body Temperature On The Neuromuscular Block Induced By Cisatracurium

ObjectiveTo investigate the influence of body temperature on the neuromuscular block induced by cisatracurium.MethodsForty ASAⅠ-Ⅱpatients(23 male,17 female) aged 27-68 yr undergoing selective abdominal surgery under general anesthesia were randomly divided into 2 groups: group I in which patients'body temperature was maintained at about 36.6℃using warming water mattress, groupⅡin which no measure were taken to maintain the patients'body temperature. The patients were premedicated with penehyclidine O.lmg/kg intravascular. Anesthesia was induced with sufentanil 0.5μg/kg, propofol 1.5 mg/kg and cisatracurium 0.15mg/kg. After tracheal intubation anesthesia was maintained with inhalation of sevoflurane and propofol infusion at a rate of 2-4 mg/kg-h.Neuromuscular block was monitored using accelngraph (Ohmeda, America). The change in T1 was monitored. When T1 returned to 25% gave cisatracurium 0.05mg/kg.The interval time was recorded. Temperature probes were placed in the nasopharynx (core temperature) and adductor pollicis. The room temperature was also recorded.ResultsThe body temperature was lower and the cisatracurium induced neuromuscular block lasted longer in groupⅡas compared with groupⅠ. There Was close correlation between body temperature and cisatracurium induced neuromuscular block.ConclusionBody temperature obviously dropped in abdominal surgery. Lower body temperature could prolong the cisatracurium induced neuromuscular block.