Clinical Study Of Erjian (HX6, 7i) Bloodletting Therapy For Exogenous Fever

ObjectiveTo evaluate objectively efficacy of clinical therapeutic effect and safety of Erjian(HX6,7i) bloodletting therapy for exogenous fever, a randomized controlled trial was undertaken.MethodsAll study objects were patients with exogenous fever. Cases source:64 patients from You Sheng Chinese clinic were selected June,2008 to December, 2009. Therapeutic methods:for group of Erjian (HX6,7i) bloodletting: selection points and Erjian(HX6,7i) points allocation:at the superior apex of anteriority folded part of helix. Operation methods:massage the apex satyri to hyperemia, use routine cotton ball of 75% alcohol to disinfect the skin, knead and clip the skin of apex satyri with left thumb and forefinger, fix the superior extremity of auricle, use the three-edged needle by right fingers, aim at the Erjian point and prick fast to the point, about 1-3 mm, then press gently with both thumbs and forefingers circumference of pinpoint to make the blood volume as bean, and use the cotton ball to draw the blood away, repeat exsanguinations until bleeding of 8 drops.Control group:Chinese patent medicine:Ganmaotuire Chong Ji. Herb Composition:Daqingye,Banglangen,Lianqiao,Quanshen. Usage and dosage:Chong Ji,10 g medicine was packed into each pouch. Adult take one pouch each time and two to three times everyday; child who older than six years use half pouch each and two times everyday; child who younger than six years use 1/3 pouch each time and two times everyday. Take medicine after mixing with warm water. Patients with syndrome of deficiency and cold of spleen and stomach are forbidden to take the medicine. The medicine was manufactured by Yuehua pharmaceutical factory in Guang Zhou. Any other drugs that have therapeutic effect are forbidden to take during the trial. The course is 5 days of both groups.ResultsThe research adapted methods of random and control to take clinical trial, and there were total 64 qualified patients including 32 cases in the trial group and 32 cases in the control group. Before treatment, all indices between two groups had no significant difference, indicating the main factors that would affect the prognosis between two groups are comparable. Total efficacy comparison:in the treatment group, the recent clinical recovery rate was 50%, excellence rate was 31.3%, and effective rate was 9.4%, recent clinical recovery plus excellence rate was 81.3% and total rate was 90.6%; while in the control group, the rate was 28.1%,28.1%,56.2% and 81.2% relatively. Comparison between two groups showed difference of significance (z=2.14, P=0.03). After five days'treatment, improvement degree of cough and thirsty symptoms had significant difference between two groups (z=2.89, P=0.00) however, improvement degree of aversion to cold, sweating and fever symptoms showed no significant difference. After treatment of five days, disappearance rate of cough (χ2=4.14,P=0.041), aversion to cold (χ2=7.27, P=0.007), fever (χ2=6.34, P=0.01), thirsty (χ2=4.51,P=0.03) pharyngalgia (χ2=4.46, P=0.03), hyperemia of pharyngeal portion (χ2=4.14, P=0.04), thick lung making by chest X-rays (χ2=4.66, P=0.03)between two groups had significant difference. While disappearance rate of chest distress, sweating, nasal obstruction, sneezing, dry stool, short and red urine, auscultation of lung breath sound showing fairly rough or a little of dry and moist rales, flare of tonsil, had no significant difference between two groups.Safety test:pre-treatment and post-treatment, there were no abnormal changes of blood routine, urine routine, stool routine, function of liver and kidney, electrocardiogram in both groups. Adverse evens observation showed no adverse reaction in both groups.ConclusionsBy the above analysis of clinical research and literature, conclusions could come to as below:Comparison with efficacy of Chinese medicine syndrome between two groups suggested the therapeutic effect of trial group is better than that in the control group. Erjian bloodletting Therapy had slight injury, suffering less, safe and without adverse effect, which could be accepted easily by patients, the method had other advantages such as microamount bleeding, economical and beneficial, simple operation and very easy to apply and popularize; the method could take effect fast and have immediately effect on some emergent symptoms; Erjian bleeding method's applicability was large and had characteristics of one method to treat multiple diseases and one point to therapy multiple diseases.