Expressions Of GSTP1 And E-cadherin In Pituitary Adenomas And Their Clinical Features

Objective To investigate the expressions of Glutathione S-transferases P1 (GSTP1) and E-cadherin and to analyze their correlations and relationships in pituitary adenomas with the clinical significance.To provide the growth and the comprehensive treatment of pituitary adenomas with molecular behavior basis. Methods A total of 60 cases of surgically resected pituitary adenoma specimens were collected during the period of July 2009 to July 2010 at the Department of Neurosurgery, Second Affiliated Hospital of Lanzhou University,Lanzhou,China. There were 30 invasive pituitary adenomas and 30 invasive pituitary adenomas,which were defined on the modified Hardy's classification. The SP immunohistochemical method was used to detect the expressions of GSTP1 and E-cadherin in 30 invasive pituitary adenoma specimens and 30 noninvasive pituitary adenoma specimens. Results Expression of GSTP1 was significantly lower in invasive pituitary adenomas than in noninvasive pituitary adenomas (P<0.05); expression of E-cadherin protein was significantly lower in invasive pituitary adenomas than in noninvasive pituitary adenomas(P<0.05); expression of GSTP1 has positive correlation with the expression of E-cadherin in pituitary adenomas(r=0.82, P<0.05). Conclusion The expressions of GSTP1 and E-cadherin are closely correlated with aggressive pituitary adenoma behavior, which are helpful for the evaluation of tumor invasion and prognosis.