Clinical Qbservation About The Method Of Generating Earth And Descending Metal In Treament The Phlegm Wet Obstructing Lung Syndrome Of CVA

Background and Objective:In recent years, The incidence of cough variant asthma (CVA) has rised due to the environment and climate factors. Because its clinical symptoms is not typical,so it is easily misdiagnosed and mistreated.The most patients are used antibiotics excessively, the disease has been brought to the forefront by the western experts. Currently CVA research which has been made some progress, but its pathogenesis is not still clear in western medicine at present. So its treatment exists certain difficulties, especially is not achieved significant progress in reducing the incidence of recurrences on CVA. But the chinese medicine adopts TCM differential treatment, not only improves symptom on clinical, but reduces racurrence.This study wihich uses generating Earth and descending Metal (Modified WenDan decoction) to treat CVA under the chinese medicine theory instruction, it unifies teacher to work Professor Yeyan many years clinical experiences. In order to explore the advantage of treating CVA by chinese medicineand test and verify the mportance of the Chinese medicine method of generating Earth and descending Metal, this study observed the therapeutical effect of the Phlegm wet obstructing lung syndrome of CVA by the Chinese medicine method of generating Earth and descending Metal (Modified WenDan decoction) compared with the Western medicine method of Experience drug with Compound Methoxyphenamine Capsules. It provides basis for evidence based medicine for clinical application of Chinese medicine. And it provides scientific evidence to decrease airway hyperresponsiveness by the Chinese medicine method of generating Earth and descending Metal.Methods:This topic selects the small sample the check experiment, forsynchrony forward-looking research. From April 2009 to April 2011 period, the Guangzhou Respiratory Disease Hospital and outpatient service, Chinese Medicine Hospital patients, collect consistent diagnostic criteria of cough variant asthma and in accordance with the chinese medicine standard Phlegm wet obstructing lung Syndrome 60 cases. The 60 cases of CVA were recruited, which were divided into two groups randomly:treatment group(30 cases)and control group(30 cases) . The treatment group was treated by the Chinese medicine method of generating Earth and descending Metal (Modified WenDan decoction);The control group by Compound Methoxyphenamine Capsules. Two weeks constituted the course of treatment. The therapeutical effect ofsyndrome and symptoms, bronchial provocation test (FEV1), the number of peripheric eosinophile(EOS) and recurring rate were observed. And statistical analysis the difference between the two groups.Results:①The total effective rate was 93.3% in treatment group, while 90% in control group. There is statistical difference between two groups by chi-square test (P<0.05).②There was improvement of cough, expectoration and throaty pruritus or foreign matter after therapy in both groups, but the treatment group was greater than the control group(P<0.05); There was no obvious improvement of tongue in control group, the effect of treatment group was much better than control group.③There were great decreased on EOS in two group after treatment,but the treatment group reduced the number of EOS which was lower than the control group, there is statistical difference (P<0.05).④There were great decreased on bronchial provocation test (FEV, ) in two group after treatment, but the treatment group decreased the airway hyperresponsiveness which was much lower than the control group, there is obvious statistical difference(P<0.01).⑤There occurred acute episode in 4 cases (13.3%) in treatment group, while 16 cases (53.3%) in control group after six month, there is obviousstatistical difference between two groups (P=0.00<0.01). The treatment group can obviously decreased the recurring rate of the Phlegm wet obstructing lung syndrome in cough variant asthma in six months.Conclusion:The therapeutical effect of method of generating Earth and descending Metal was better than the control group in treament of Phlegm wet obstructing lung syndrome in cough variant asthma; which might decrease airway hyperresponsiveness and obviously decreased the recurring rate in six months, and improve the prognosis of patients, so to achieve permanent by TCM.