| BackgroundsWith the rapid development of endoscope technology, endoscopy has now become the main method of discovering gastrointestinal polyps. And the most common disease found in colonoscopy is colorectal polyp for its increasing detection rate. Colorectal polyps are a kind of uplift-shaped lesions extruding from the surface of mucosa to enterocoel, among them, adenomatous polyp acts intimately with colon cancer. As early as one hundred years ago. Dukes presented that villous adenoma polyp would ceaselessly transform to malignant tumor despite of its benign characteristic at early stage. "Adenoma-Cancer" Sequence Theory presented by Morson has got wide recognition. Colon cancer is one of the common malignant tumors in digestive system all over the world, and its detection rate shows increasing trend. So it is crucial to discover and treat adenomatous polyps at early stage for prevention of colon cancer. Colorectal polyp is hard to detect at early stage, since its clinical feature is occult, atypical and nonspecific. Common examination involves Occult Blood Test, double contrast barium enema. CT examination, and colonoscopy. but the most direct and precise examination is colonoscopy. However, many patients are afraid of it because of huge pain brought by it. So how to find these patients is our main problem. This article retrospectively analyzed the colonoscopy and some serology data from staffs of Ningbo petrochemical enterprise diagnosed in our hospital from 2009 March to 2010 September, in order to realize the relative clinical factors of colorectal polyps in the enterprise and offer proof for clinical diagnosis and treatment of colorectal polyps.ObjectiveTo discover colorectal polyps by colonoscopy and learn the relationship between colorectal polyps and indexes such as sex, age, occupational hazard (hydrogen sulfide), smoking, drinking, lower gastrointestinal symptom, waistline, BMI and blood lipid.MethodsWe retrospectively analyzed the cases such as height, weight, waistline, drinking, lower gastrointestinal symptom, indexes such as total cholesterol, triglyceride, blood sugar, hs-CRP, urea nitrogen and whole enteroscopy results of 1,962 staffs diagnosed in our hospital from 2009 March to 2010 September. We used SPSS 11.5 to describe and analyze the data of total population, sex and age, and used chi-square test to exam enumeration data. The statistical results were significantly different when P<0.05.Results(1) Total detection rate of colorectal polyp was 15.39%,17.73% for male, and 12.23% for female. The difference was statistically significant (P<0.01); The detection rate of colorectal polyp increased gradually with the increasing age, the corresponding values were 7.89% in youth group.14.26% in middle-aged group and 20.39% in older group, The differences were statistically significant (P<0.01).(2) The detection rate of colorectal polyp among exposed to hydrogen sulfide was 15.05%, compared with 19.59% among unexposed group. There was no statistical difference by chi-square test (P>0.05).(3) There were 351 cases with lower gastrointestinal symptoms, most of which was constipation. Dividing subjects into two groups based on the presence of symptom or not, and the detection rates were respectively 15.10% and 15.46%. There was no statistical difference between the two groups (P>0.05).(4) The detection rates of the smokers and non-smokers were 20.44%,13.69% separately, both of which were significant in statistics (P<0.01). At the same time, the detection rates of regular drinkers and non-drinkers were 19.62%,14.56%, the detection rates of the colorectal polyps between these two groups are significantly different (P<0.05). The detection rate of the group with non-smokers and non-drinkers was 13.46%; the rate of the only-drinking group was 18.42%; the only-smoking group was 21.12%; the group of smokers and drinkers was 20.00%. Comparing with the latter two groups, the first group was significantly low in statistics (P<0.05,respectively). There was no statistic difference between the remaining two groups.(5) The detection rates of normal body mass index group and obesity group were respectively 15.28%,15.65%,there was no statistical significance (P=0.837); Waistline normal group and abnormal group respectively accounted for 13.36%, 17.98%, there was a statistical significance (P<0.01).(6) According to the metabolic markers, subjects can be categorized into normal group and abnormal group,the detection rates werel3.29% and 18.28% based on total cholesterol level;13.19% and 18.89% based on low density lipoprotein;14.83% and 23.35% based on fasting blood-glucose;14.89% and 21.83% based on high density lipoprotein. There were significant differences between all of the two groups (P<0.05). The detection rates of normal and abnormal triglyceride were respectively 14.87%. 16.82%;hs-CRP were 14.96%,20.12%;uric acid were 15.34%,13.53%,there was no statistical significance between each two groups above (P>0.05).Conclusions(1) The detection rate of colorectal polyps is correlated with the age as well as the sex. The older the people are, the higher rate they will be detected the colorectal polyps. Comparing with women, men are more likely to develop colorectal polyps. (2) In the producing process of Ningbo petrochemical enterprise, the hydrogen sulfide which is the main environmental factor has no adverse effect on the colorectal polyps of the staffs. (3) Lower gastrointestinal symptoms can't be the evidence for the diagnosis of the colorectal polyps, but they can provide clues and references for the diagnosis. The application of the colonoscopy should be extended. (4) Smoking and drinking have a certain impact on the formation of colorectal polyps. Either simple smoking or both smoking and drinking does more harm than simple drinking. (5) To assess risk factors for colorectal polyps, waistline may be more accurate than body mass index(BMI). (6) Total cholesterol level, low density lipoprotein and fasting blood glucose are positively correlated with colorectal polyp, while high density lipoprotein is adversely correlated; triglyceride, crp and uric acid have no correlation with colorectal polyps. |
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