| Objectives: In previous subject "spleen cholagogue piece of treatmentcholecystitis clinical and experimental research" basis, Expand further clinical observation cases, increased the drug for gallbladder shrinking grain (CCK) researches on the effects of the drugdevelopment, at the same time according to requirements, perfect preparation technology, quality standards, increase the drug toxicology experiment for the development of Chinese medicine three new drugs do into preparation.Methods: 100 patients with TCM syndrome differentiation type cholecystitis for pixu patients were randomly divided into trial group (taking the spleen cholagogue pieces), the control group (taking cholagogue piece), observed before and after treatment main clinical symptoms and signs of improvement, Before and after the treatment gallbladder B ultrasonic imaging change, Before and after the treatment CCK level detection. Blood, routine urine and liver, kidney of safety inspection.Results: Clinical observation results showed that patients and controls the comprehensive effect of clinical and greater rate and the total effective rate was 78%, 92 percent, respectively, the 62.00%, 72.00% and inspection, there is significant X~2 difference (P = 0.046, P < 0.05). 4.75%more curative effect that better than control group. The two groups of the curative effect of traditional Chinese medical syndrome and greater rate and total 82.00%, 96.00% 50.7%and 66.00%, by 76.00%, and inspection, significant X~2 difference (P < 0.05). That was better than control group curative effect. After treatment, the two groups were compared in the group TCM symptoms are integral with extremely significant difference (p = 0.00 observation group and the control group (p = 0.00, p < 0.01); The two groups that drug treatment they improve the clinical symptoms. After treatment, the two groups were compared between groups TCM symptom scores before and after integral poor healing healing comparison, difference value extremely significant (after treatment, p = 0.00 therapy after integral differential value before therapy, p = 0.00, p < 0.01). In that improving patient group was better than control of clinical symptoms. The main symptoms were have improved, TCM by X~2 inspection, trial group and control group right flank sore or discomfort, wan abdomen bilge fall after home, food ShaoHua, pale bulge, god with total effective weary force 96.00% symptoms were 98.00%, 90.00% and 62.00%, ecological, 78.00%, each, compared the differences are significant (P < 0.05), and the main symptoms of the group to improve better than control. In the recovery gallbladder B to exceed normal form, under the two groups of patients after treatment, the longitudinal diameter, gallbladder diameter, longitudinal diameter/horizontal diameter situation in group a, group compared with extremely significant difference were compared longitudinal diameter (p = 0.00, horizontal size comparison p = 0.00 longitudinal diameter/horizontal diameter p = 0.00, p < 0.01); Controls the longitudinal diameter, has been in the group diameter longitudinal diameter significant differences (p = 0.047, compared the size comparison p = 0.001, p < 0.05), but the longitudinal diameter/diameter value no significant differences. 0.113 (p = > 0.05), p; After treatment, the two groups of patients gallbladder longitudinal diameter, horizontal diameter, longitudinal diameter between groups/the diameter situation compared with extremely significant difference between groups of longitudinal diameter (p = 0.00 comparison, horizontal diameter p = 0.00 longitudinal diameter/horizontal diameter p = 0.00, p < 0.01). Explain the longitudinal diameter, 4.75%more gallbladder diameter and the diameter of the longitudinal diameter/are both a control group were obviously improved. The change in the gallbladder contraction element, after the treatment situation in two groups of patients gallbladder contraction in group a, meal group comparison was significant difference (p = 0.00, p < 0.01); No significant differences in control group (p = > 0.05) 0.827, p; Two groups of patients before and after the treatment of comparison between gallbladder contraction element before and after healing poor cost comparison, healing greup (group is compared between p = 0.00 therapy after former therapy compared p = 0.00 poor value, p < 0.01). Explain in improving the gallbladder group was better than control shrinking grain aspects.Conclusion: the spleen lidan piece not only can significantly improve systemic symptom, and can greatly improve the level of gallbladder contraction element, restore normal form under b-sonography gallbladder, confirmed the spleen lidan slice of the spleen cholagogue with the exact role, have had better clinical curative effect. |
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