The Clinical Observation On The Treatment Of Mild-to-moderate Cancerous Pain With External Application By Detumescence â… 

ObjectiveChinese medicine hospital in Hubei Province by the 80 patients with mild to moderate pain in cancer patients randomized, controlled clinical study to Detumescence I on external side topical mild to moderate clinical efficacy of cancer pain, in order to provide evidence-based clinical medical basis.MethodsFrom October 2008 to October 2009, a total of 80 patients completed the study, included in the study of mild to moderate pain in cancer patients were randomly divided into treatment group and control group, both are the same basic therapy, all intravenous drip of anti-tumor medicine, and depending on the individual situation of oral to blood circulation, reduces swelling, pain, reconcile the yin and yang of Chinese herbal medicine-based soups and be the corresponding symptomatic supportive care. Treatment group:in the basic treatment based on the WHO recommended three-step analgesic therapy, taking one, two ladder drugs, refer to the instructions of conventional-dose administration of drugs, and external application of Detumescence I on external parties. Control group:in the basic treatment based on the WHO recommended three-step analgesic therapy, take one, two ladder drugs, refer to the instructions of conventional-dose administration of drugs, respectively, before treatment and medication records of patients 24 hours after the pain intensity, drug onset time, sustained pain relief time, the best time of pain, quality of life and adverse reactions.Results1. Detumescence I on external side and a second step the efficacy of oral drug therapy no difference (P>0.05), treatment efficacy and stability, the treatment group 40 patients total effective rate of 38 cases (95.00%), the control group of 40 patients with total effective 37 cases (92.50%).2. Detumescence I external side of swelling onset time, the best pain relief in a short time, second stairs medication group (P<0.001). The two groups had no statistical difference in pain duration (P> 0.05).3. Detumescence I on external side in different parts of the efficacy of cancer pain was no significant difference (P>0.05). Mild pain on the efficacy of the efficacy of more than moderate pain (P<0.05).4. Detumescence I external swelling may significantly improve patient quality of life, emotional and sleep are better than the control group, and in nausea and vomiting, dizziness and constipation in the incidence of adverse reactions was significantly lower than the control group (P<0.05). Detumescence I swelling of skin external application group does not appear serious adverse reactions.Conclusion 1. Detumescence I external application with an external party, second stairs medication with a simple one, second stairs medication compared to obtain synergies, analgesic onset time is short, to achieve the best pain relief time is short.2. Detumescence I external application with an external party, second stairs medication can significantly improve the quality of life of patients, and adverse reactions is small, the combined effect of the good.3. Detumescence I on external use side effects than mild pain, moderate pain.