| Objective:To investigate the effect of Carboxyl methyl Chitosan in hypertrophic scars by establishing hypertrophic scar model on the ventral side of rabbit ears.Methods:Full-thickness excisional wounds,1 cm in diameter,were made in the ears of 12 adult New Zealand white rabbits. A total of 123 hypertrophic scars were made. Then the rabbits were divided into 3 groups:group A is experimental group (Carboxyl methyl Chitosan,500μg/ml), group B is significant group (Triamcinolone), and group C is control group (physiological saline).All the scars were injected with drugs on the 30th and 40th days after operation, then were collected on the 35th and 45th day and analyzed.Results:Compared with group C, group A appeared to be flatter, softer,and lighter in color;We can see the area density of collagen decreased using HE stain and Masson stain (P<0.05), hydroxyproline content and hypertrophic index was lower than group C (P<0.05). There were no significant differences on those criterions between group A and group B (P>0.05).Conclusion:To inject Carboxyl methyl Chitosan in local hypertrophic scars on rabbit ears had similar effects compared with triamcinolone.Whether it can be a substitute of triamcinolone in therapeutic usage over curing hypertrophic scars in human still requires further studies. |
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