Clinical Study Of Measuredvalue Of Lymphatic Vessel Density And Microvessel Density In Pancreatic Carcinoma Tissue

Objective:To study the changes of the Lymphatic vessel density(LVD) and microvessel density(MVD) and the relationship with the clinical pathology parameer and their interaction.Methods:The LVD and MVD were detected by using monoclonal antibody D2-40 and CD34 in 41 patients with pancreatic ductal adenocarcinoma by using immunohistochemical method SABC. The expression of LVD and MVD in the cancer, paraneoplastic and normal pancreatic tissue were analyzed relationship with the clinical pathology parameter like as the pathological stage, tumor differentiation and lymph node metastasis, and the correlation between the LVD of paraneoplastic and MVD of cancer tissues.Result:The average LVD of cancer, paraneoplastic and normal pancreatic tissue were 11.244±4.800,15.829±7.470 and 13.512±5.139 respectively in 41 cases, in which significant differerce was found between the paraneoplastic and cancer tissue (P=0.000< 0.01) and contrary between paraneoplastic and normal pancreatic tissue (P=0.060> 0.05). The mean MVD value in paired cancer and normal pancreatic tissue were 46.585±16.935,11.100±4.036 respectively. The statistically significant difference was found between the two groups (P=0.000<0.01). The mean MVD value in paired cancer and normal pancreatic tissue were 46.585±16.935,11.100±4.036 respectively. The statistically significant difference was found between the two groups (P=0.000< 0.01).Correlation was found between the LVD values of paraneoplastic tissues and the MVD values of tissues(P=0.025<0.05).Conclusion:The LVD values and MVD values of pancreatic ductal adenocarcinoma were associated with the tumor differentiation, pathological stage and lymph node metastasis. The LVD values of paraneoplastic tissues was correlated with the MVD values of pancreatic cancer tissues.