The Retrospective Research On The Gastric Cancer Cases Treating By Professor Zhou Zhongying Based On Data Mining

Objective:To summarize Professor Zhou Zhongying's academic idea and clinical experience in diagnosing and treating gastric cancer which can give a helpful guidance to modern TCM treatment in gastric cancer on the basis of his clinic practice for dozens of years and modern data mining technology.Methods:Through long time study following in Professor Zhou Zhongying, all gastric cancer cases from his clinic in later three years were collected. According to include and exclude criteria,180 cases were picked up and established a gastric cancer database. In order to find out the rules of syndrome, pathogenesis, symptom and medication, data mining technology like frequencies, factor analysis and association analysis were used. The analysis results were discussed and summarized combined with Professor Zhou's clinical experience.Results:All 180 cases of gastric cancer,130 are male and 50 are female, the average age is 61.03±12.25 years old. According to frequency analysis results, the pathogenesis over 30% includes blood stasis, heat, dampness, phlegm and cancerous toxin.In the aspect of syndromes, the frequent deficiency syndromes are deficiency of spleen and stomach, insufficiency of qi and yin, which take 48.33% and 52.78% respectively; the frequent excessive syndromes are obstruction of dampness and heat, accumulation of cancerous toxin and blood stasis, which takes 41.11% and 27.78% respectively.198 drugs were used in all 180 cases which focus on anti-cancer, relieving toxin, soothing liver-qi, clearing heat and dampness, removing phlegm and blood stasis, replenishing qi and nourishing yin.Conclusions:According to this study, obstruction in stomach by cancerous toxin is the key of pathogenesis. Qi deficiency and retention of cancerous toxin is the basis of morbidity. As basic pathologic factor, cancerous toxin is always combined with other pathologic factors and form combined pathogenesis like cancerous toxin with blood stasis, cancerous toxin with heat, cancerous toxin with dampness, cancerous toxin with phlegm and cause the disease. The essential syndromes include disharmony of liver and stomach, obstruction of dampness and heat, retention of phlegm and blood stasis, accumulation of cancerous toxin and blood stasis, deficiency of spleen and stomach, insufficiency of qi and yin. The syndrome of qi deficiency and yang exhaustion is seldom but special.In the aspect of treatment principle, the basic principle is to anti-cancer and relieving toxin, strengthening vital qi. Based on dredging and descending stomach qi, decoction according to combined treating principles should be formulated. In the aspect of medication, drugs for anti-cancer and relieving toxin should be used in the whole stage. The common-used drugs include Xianhecao, Sheshecao, Shidachuan, Zeqi, Shancigu, Zhongjiefeng, Banzhilian, Zhinanxing, Weilingxian, Hongdoushan, Dujiaoqianglang and so on.The principle of regulating qi and relieveing the depression also play an inportment part in the whole treatment.