Resting-state Functional Magnetic Resonance Imaging Of Sensorineural Deafness Patients

Objective: To observe the activated brain areas of normal hearing subjects and the sensorineural deafness patients with resting-state brain functional magnetic resonance imaging (REST fMRI), and to compare the differences between them.Materials and Methods: Both the normal hearing subjects and the sensorineural deafness patients were scaned with GE 3.0T MRI scaner to get routine T2WI and REST fMRI images. To observe the intensity and MNI coordinates of the activated areas, then make appropriate statistical analysis between the two groups.Results: 1 The normal hearing subjects. ALFF activated brain areas are: Bilateral middle frontal gyrus, bilateral inferior parietal praecuneus, bilateral inferior parietal lobule, right anterior cingulate gyrus, right posterior cingulate gyrus and right inferior frontal gyrus; ReHo activated brain areas are: Bilateral inferior parietal praecuneus, bilateral parietal angular gyrus, bilateral posterior cingulate gyrus, right anterior cingulate gyrus, right middle frontal gyrus and right inferior frontal gyrus.2. The sensorineural deafness patients. ALFF activated brain areas are: left inferior frontal gyrus, left middle temporal gyrus, left parietal lobe angular gyrus, right posterior the central gyrus, right posterior cingulate gyrus; ReHoactivated brain areas are: Bilateral occipital cortex, left parietal lobe angular gyrus, left superior temporal gyrus, left inferior parietal lobule, right posterior cingulate gyrus, right anterior cingulate, right middle frontal gyrus, right inferior parietal lobule supramarginal gyrus.3. Difference between the normal hearing subjects and the sensorineural deafness patients. In Normal subjects, Stronger activated ALFF brain areas than sensorineural hearing loss patient were found in: Left middle frontal gyrus, left posterior cingulate gyrus, right superior frontal gyrus, right middle frontal gyrus, right inferior parietal lobule, right inferior parietal lobule supramarginal gyrus; In Normal subjects, Stronger activated ReHo brain areas than sensorineural hearing loss patient were found in: Bilateral middle frontal gyrus, bilateral anterior cingulate gyrus, left parahippocampal gyrus, leftnferior parietal lobule supramarginal gyrus, right inferior parietal lobule, left posterior cingulate gyrus.Conclusions: 1. Posterior cingulate and adjacent praecuneus, angular gyrus, ventral anterior cingulate and prefrontal lobe constitute a default state of the network in normal resting state.2. There were different activated brain areas between sensorineural deafness group and the normal hearing group, which suggest cortex reorganizations in the sensorineural deafness subjects.