| Objective:Comparison of clinical efficacy and safety of modification of Chushi Weiling Decoction combined with western medicine and western medicine alone cureing Spleen wet Yun subacute eczema. To be adopted by the research to find safer, more effective method of treatment of eczema, to be able to play a guiding role in the clinical. Method:54 patients were selected from Eczema Specialist Outpatient Clinics and wards, Wuhan First Hospital. All patients were met the diagnostic criteria for eczema and belonged of Spleen wet Yun card through the TCM. Patients were randomly divided into treatment group and control group, treatment group,30 cases, in the control group 24 cases. The two groups in gender, age, course of disease, eczema area and severity index (EASI) score was no significant difference (P>0.05), comparable. Treatment group:Oral modification of Chushi Weiling Decoction, day 1, divided into morning and evening to take; SNMC ived,80mg per-use (With the calculation of the amount of Glycyrrhizin), in 250ml of 5% glucose injection or Saline injection,1 time/d; chlorpheniramine oral tablets 4 mg/time,3 times/d, Topical triamcinolone acetonide acetate ointment compound and compound zinc oxide liniment.Control group:SNMC ived while chlorpheniramine oral chlorpheniramine tablets tablets, usage with the treatment group and for external use with the treatment group. Treatment for the 2w.Through effective rate, change of itching symptom before and after treatment, efficiency and the incidence of adverse reactions, relapse rate assessed for statistical analysis to observe the effectiveness, safety.Rusults:1. Effective rate:the treatment group cured 16 cases, effective in 10 cases, improvement in 3 cases, ineffective in 1 case, efficiency rate 86.67%; The control group healed in 7 cases, markedly effective in 8 cases improved in 8 cases, ineffective in 1 case, efficiency rate 62.50%. The treatment group were more efficient than that in control group significantly. Comparing the efficiency of two groups by theχ2test, P<0.05, statistically significant differences; the treatment group were more effective than the control group.2. Comparison of pruritus score:comparison of the scores between the two groups before treatment, (P>0.05),no significant difference;the comparison in the group of the each group after 1 week treatment (P<0.01),the difference was significant, noteing the itching degree of treatment group and control group reduced significantly after treatment; After 2 weeks of treatment the treatment group compared with control group(P<0.05),there was significant difference, indicating the treatment group was better than the control group in the degree of itching improvement.3. The incidence of adverse reactions:the treatment group occurred in 4 cases, the incidence of 13.33%; the control group occurred in 2 cases, the incidence of 8.33%. Comparing the two groups by theχ2test (P>0.05), the difference was not statistically significant.4. Relapse rate:Follow-up of patients cured in treatment group and control group 2 weeks after the completion of treatment. The treatment group 16 cases,2 cases of recurrence, the recurrence rate of 12.50%, control group,7 cases,2 cases of recurrence, the recurrence rate of 28.57%. Relapse rate compared between two groups:P>0.05, the difference was not statistically significant.Conclusion:Clinical observation of the subject shoued that in the treatment of Spleen wet Yun subacute eczema on the basis of conventional treatment combined with modification of Chushi Weiling Decoction, Status of patients with skin lesions, itching indicated of the degree of improvement to be better. Clinical studies proved to be effective, safe and worthy of popularization. |
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