The Effection Of Nephrin's Expression About Nephrms Xiaobaikeli To Adriamycin Nephropathy Glomeruli Of Rats

Objective:To test if nephritis Xiaobaikeli decreases proteinuria level in experimental animals and investigate its mechanism by biochemical and molecular biological analysis to provide the basis for its clinical application.Methods:We utilized a rat model in which nephritis is induced by one-time tail vein injection of doxorubicin.Animals were divided into five groups,namely the naive control group,model control group,Lotensin group,low-dose nephritis Xiaobaikeli group and high-dose nephritis Xiaobaikeli group.Seven weeks after treatment,we detected rat urine creatinine,urine Scr,urineβ2-MG(by ELISA),proteinuria,Nephrin expression in kidney(by immunohistochemical staining),.Results:At the end of 7-week observation,the ratio of proteinuria/urine creatinine values(P<0.05)were reduced in animals from all treatment group with doxorubicin-induced nephritis,and the high-dose nephritis Xiaobaikeli treatment had the most significant effects(P