Treatment Of 26 Cases Of Obstructive Sleep Apnea - Hypopnea Syndrome By Modified Xuefuzhuyu Decoction

ObjectiveSelected in accordance with TCM syndrome of qi deficiency blood stasis type of obstructive sleep apnea hypopnea syndrom (OSAHS) patients, using traditional Chinese medicine prescription Xuefu Zhuyu Decoction for treatment, through observation the changes of the AHI, LSaO2, TCM symptom scores, BMI and other changes,to investigate efficacy of Xuefu Zhuyu Decoction in the treatment of qi deficiency and blood stasis of OSAHS patients, provide the basis for system of TCM.method:Subjects of the study are come from the outpatients and inpatients of Ministry of Health, Beijing Hospital during December 2013 to January 2016.Selected patients from among them who snore and who has typical OSAHS clinical manifestations and can be diagnosed OSAHS with polysomnography (PSG) examination, screening in accordance with TCM syndrome differentiation of traditional Chinese medicine for patients with Qi deficiency and blood stasis type as the object of study.Finally,there is a total of 34 patients enrolled.Then, depending on whether the patient is willing to accept the decoction of Chinese medicine treatment, divided into treatment group(26 cases) and control group(7 cases), the treatment group treated with Xuefu Zhuyu Decoction, and control group was not given any treatment for OSAHS, After a month,let the patientsagain underwent PSG monitoring and assessment of clinical symptoms. By using SPSS Statistics 20 statistical software for statistical data and analysis to assess the overall effect after treatment, the efficacy of TCM symptoms, symptoms of each case, before and after the treatment of apnea-hypopnea index (AHI), lowest oxygen at night (LSaO2), body weight the change index (BMI) and other indicators.results:After treatment, the overall effect of the two groups are statistically significant (P< 0.01), treatment group of 26 patients,0 cases markedly effective, effective in 17 cases,9 cases ineffective, effective rate was 65.4%, control group of 7 patients,0 cases markedly effective, effective cases, invalid in 7 cases. Among them, the treatment group 6 patients with mild all effective, the total efficiency of up to 100%; 4 cases of patients with moderate effective in 3 cases,1 case was ineffective, the total effective rate was 75%; 16 cases of severe patients,8 cases were effective,8 cases were ineffective. The total effective rate was 50%. Course less than 5 years,2 cases were effective, the total effective rate was 100%; course in 5-10 years (including 10 years) of the 14 patients,10 cases were effective,4 cases ineffective,71.4% efficiency. The course of disease in more than 10 years of 10 patients,5 cases were effective, invalid in 5 cases, the total efficiency of 50%.There were no significant differences in the two groups before treatment (P> 0.05),comparable.The relatively prompt treatment in reducing AHI, increase LSaO2, improve clinical symptoms, the treatment group was significantly better than the control group, P <0.05. The two groups before and after treatment no significant change in BMI,consider ing that the effect of traditional Chinese medicine to improve BMI is not obvious.Symptoms,treatment group has a significant effect in improving "snoring", "Night suffocation" improvement "lassitude", "less gas lazy words," "eat less poor appetite," "Burnout lethargy" with tongue and pulse and other symptoms,P<0.05, the difference was statistically significant; while the control group had no significant changes in various symptoms, P> 0.05, the difference was not statistically significant. Compared The treatment group with control group,we found the different in improving "lassitude", "Burnout lethargy" and other symptoms, P<0.05, while patients from the tongue color, tongue, the sublingual collaterals and pulse has also been significantly improved.And from the tenderness of tongue the assessment of patients we know their Qi deficiency and blood stasis syndrome get a certain improvement.It is speculated that. If they insist on long-term medication, they may have some long-term effects.ConclusionXuefu Zhuyu Decoction have a certain effect of treating OSAHS with Qi deficiency and blood stasis, it can improve clinical symptoms, reduce the AHI index, improve LSaO2, mild and short course of patient outcome significantly. Therefore, early treatment of Chinese medicine, can improve the overall condition of the patient, reduce symptoms, improve quality of life. Due to limited time, limited funding reasons, small sample size of this study,and we did not follow the principle of double-blind randomized, no long-term follow-up, we can not determine the long-term efficacy of traditional Chinese medicine treatment of the disease, and about active ingredient of Xuefu Zhuyu Decoction is not clear, so, so, we still need more further study.