New Molecularly Imprinted Polymer Synthesis And Performance Testing

The dissertation is divided into five chapters, and they are: (1) an overviews of the development of research in molecularly imprinting polymers; (2) synthesis of 1D nanostructures by using alumina membrane and the progress of atom transfer radical polymerization; (3) synthesis of magnetic molecularly imprinted polymer nanowires using a nanoporous alumina template; (4) preparation of polymer nanowires with the imprinted protein molecule and surface binding sites; and (5) the preparation of magnetic molecularly imprinted polymer nanoparticles by surface-initiated atom transfer radical polymerization (ATRP) and template synthesis of molecularly imprinted polymer nanotube membranes for chemical separations using surface-initiated atom transfer radical polymerization.The first chapter is an introduction of the whole dissertation, and it is composed of four parts. The first part is an overview of the development, synthesize route, application and research hotspots of molecularly imprinted polymerization. The second part is an overview of the principle of 1D nanostructures synthesis using alumina membrane template. The third part is an overview of the principle, influence factors of atom transfer radical polymerization and an introduction of surface-initiated atom transfer radical polymerization. The fourth part describes the purpose, significant and innovation of the dissertation.In chapter 2, a method for the synthesis of magnetic molecularly imprinted polymer nanowires using a nanoporous alumina template is presented. The magnetic polymer nanowires containing theophylline binding sites uniquely residing at the surface were prepared using alumina membrane as the template. The superparamagnetic nanocrystallites can be well entrapped in the nanowires. The magnetic, molecularly imprinted polymer nanowires developed in this study could have potential applications in drug delivery, drug release, and for trace enrichment of specific target molecules in biochemical application.Chapter 3 describes a technique for the preparation of polymer nanowires with the protein molecule binding sites on surfaces. Since the protein imprinting sites are located at, or close to the surface, these imprinted nanowires have demonstrated good site accessibility toward the target protein molecules. Furthermore, the large surface area of these imprinted nanowires results in large capacity for protein molecule binding.In chapter 4, an approach for making magnetic molecularly imprinted polymer nanoparticles by surface-initiated atom transfer radical polymerization (ATRP) is discussed. Results showed that ATRP works very well to form molecularly imprinted polymer shell on nanoparticles MnFe2O4 and produces magnetic/molecularly imprinted polymer core/shell nanoparticles with particle size less than 20 nm. These nanoparticles can be directly used in magnetic separating sorbent assays and for rapid trace enrichment of specific target molecules in biochemical application. Moreover, the resulting nanoparticles are within the biological size restrictions and thus have potential use in controlled drug delivery and drug release.In chapter 5, the application of template synthesized molecularly imprinted polymer nanotube membranes in chemical separations is reported. The experimental results prove that atom transfer radical polymerization route works well in the formation of molecularly imprinted polymer nanotubes within porous alumina template. The advantages of the high affinity and selectivity of the molecular imprinted polymer nanotube membrane in chemical separation are also discussed.