The Clinical Effect And Experimental Study On Et Level Of Patients With Stable Angina Pectoris Treated By Shenqifuzheng Injection

Objective:To discuss the elementary pathogenesis of stable angina pectoris with the syndrome of qi deficiency and the method of supplementing qi to treat angina pectoris, study the curative effect mechanism of Shenqifuzheng injection on clinical symptom and ET level in patients and discuss part of its clinical mechanism.Methods:A total of 60 angina pectoris patients with the syndrome of qi deficiency were observed. They were divided into two groups at random. The treatment group and the control group both had 30 patients. There was no obvious difference in age, sex, illness course and severity degree between the two groups. The treatment group received Shenqifuzheng infection treatment. The control group received Shenmai injection. The changes of clinical symptoms and laboratory indexes in all patients were observed before and after treatment.Results:The treatment group was better than control group in overall effective rates of angina pectoris (93.3% vs 90.0%) and electrocadiogram effective rate (73.3% vs 63.3%). At the aspect of treatment effect of traditional medicine, both groups could ameliorate the symptoms of angina pectoris of type qi deficiency such as chest pain, chest distress, short breath and so on. But between the experiment and control groups there was no significant difference. The control group was better than treatment group in the effective rate of reducing use rate of Nitroglycerin (76.6% vs 83.3%).But there was no statistical difference between the two groups (P>0.05). In endothelium function, ET decreased. They were better and had remarkable difference than before treatment (P <0.01). Compared between the two groups, there was no statistical difference. In side effects, no obvious and serious side effects were found.Conclusions:Shenqifuzheng injection has specific effect in treating angina pectoris patients with the syndrome of qi deficiency. It operates through improving myocardial ischemia and regulating endothelium function. It is a safe and effective preparation and it is worthy to be studied deeply.