Sini San Promote Gastrointestinal Motility Effect And Mechanism Of Experimental Research

Object:Dysfunctional Dyspepsia is a group of dyspepsia symptoms caused by nonorgan pathological changs.The cause of it does not definite.So far,we have beening lakeing effective remedies for curing it. There is no name about the illness in the TCM,but according its clinical symptom, it belong to the syndrome of the stomachache, the stuffiness in the stomach,the scarcity desire of the dining, the gastric upset, the frequent vomiting, the spewing, the hiccup and so on.The fundamental pathogenesis of it is the liver-qi stagnation the spleen-qi deficiency and the stomache-qi ascending adversely. During this years, TCM has a prominent effect on Dysfunctional Dyspepsia,so we study the effect of SiNiSan of soup on the Dysfunctional Dyspepsia sharply from the ability of stomach emptying and the ability of intestines pussing on the normal Kunming rats by the coloring matter,and the chang of the nerve fiber, nerve qualitative, on the stomach organize of normal SD ratsMethods:In the experiment, the thirty Kunming rats, whose avoirdupois are about twenty grammes,and thirty S. D rats, whose avoirdupois are about two hundred grammes,were randomly divided into three groups, 0. 9yS group, SiNiSan of soup group and Mosapride Citrate group. Every gro-up had ten rats and was dealed with water, SiNiSan of soup and Mosa-pride Citrate. At last,we study the effect of the ability of stomach emptying and the ability of intestines pussing on the Kunming rats.An-d we study the chang of the intestines constract scope and frequency of the norml SD rats, the chang of the nerve fiber, the nerve qualitative, on the stomach organize of the normal SD rats The statistical method are F test and Q test.Result:The experiment of gastric emptying rate on mouse has showed thatSiNiSan of soup could promote he gastric mptying ate,there was very remarkable differentce between the SiNiSan of soup group and the normal group (p<0.01),and there was not significant difference between the SiNiSan of soup group and the Mosapride Citrate group (p>0. 05). And there was very remarkable differencebetween the Mosap-ride Citrate group and the normal group(p<0. 01).The experiment of intestines pussing rate on rat has showed that SiNiSan ofsoup could promote the intestines pussing rate, there was remarkable difference between the SiNiSan of soup group and the norma 1 group(p<0. 05),and there was not significant difference between the SiNiSan of soup group and the Mosapride Citrate group(p>0.05).And there was very remarkable difference between the Mosapride Citrate group and the normal group(p<0. 01).The experiment of the intestines constract scope and frequenc has showed that SiNiSan ofsoup could promote the intestines constract scope and frequenc, there was very remarkable difference between the SiNiSan of soup group and the normal group(p<0. 01),and there was not significant difference between the SiNiSan of soup group and the Mosapride Citrate group(p>0. 05).And there was very remarkable difference between the Mosapride Citrate group and the normal group (p<0. 01).The experiment of the NOS masculine nerve fiber distributing area and enzyme active that SiNiSan ofsoup could reduce the NOS masculine nerve fiber distributing area and enzyme active there was very remarkable difference between the SiNiSan of soup group and the normal group (p<0. 01), and there was not significant difference between the SiNiSan of soup group and the Mosapride Citrate group(p>0,05).And there was very remarkable difference between the Mosapride Citrate group and the normal group(p<0. 01).The experiment of the stomach organize NO, TchE content has showedthat SiNiSan ofsoup could reduce NO content and promote tHe TchE content there was very remarkable difference between the SiNiSan of soup group and the normal group (p<0. 01), and there was not significant difference between the SiNiSan of soup group and the Mosapride Citrate group(p>0. 05). And there was very remarkable difference between the Mosapride Citrate group and the normal group (p<0. 01).Conclusion:...