Pulse Of The High Sugar High Fat And Cholesterol Diet Dm Lipid Metabolism And Femoral Artery Morphology

Objective: To investigate the affection of Maitongfang on certain related factors which can cause DLASO, mainly on the affection on glycometabolism, lipometabolism, oxidative stress and function of blood platelet. Methods: The SD rats were fed with high-sugar, high-fat and high-cholesterol feeding stuff, and then induced by Alloxan intraperitoneally to be diabetic rat models. The rats were randomly divided into five groups, ie. Model control, low dosage of Maitongfang, high dosage of Maitongfang, and Cilostazol group respectively. Normal control group was also established. The effect of different medicines on the following parameters were detected by radioimmunoassay, biochemistry detect method, Histomorphometry, etc. which were serum level of insulin, TC, TG, HDL-C, Lp(a), SOD, MDA, TXB2, 6-Keto-PGF_1a, tectology of femoral artery, changes in general condition and blood glucose as well. Results: The abnormalities of most of the parameters stated above were shown in DM rats, as well as the pathologic changes of femoral artery. While Maitongfang demonstrates the action of improving the general condition, regulating the metabolism of blood glucose and blood lipid, strengthening the cell's ability of antioxidation, improving the function of platelet aggregation. The comprehensive curative effect of Maitongfang is superior to that of Cilostazol group. Conclusion: Through the regulating action of many pathways and links which presented as decreasing or inhibiting accumulation of lipid on Tunica intima of artery, protecting the integrity of the structure of blood vessel endothelial cell effectively, preventing artery vessel spasm and formation of thrombosis, Maitongfang contributes to the prevention and treatment of DLASO.