Compound Curcuma Red Capsule Treatment Of Migraine Clinical And Experimental Research,

ObjectiveComplex E'Hong Capsule(CEHC) is an experience prescription of Pr. Wan Yuan Tie treating migraine. It has gained obvious effect in clinic use. This subject will study the use of alleviating pain, tranquilizing and relieving convulsion about .To investigate the pharmacodynamic effects of CEHC on activing blood circulation to dissipate blood stasis. CEHC and probe the mechanism of assuaging pain and safety about CEHC through acute toxicity test. Supply the theory foundation for it's popularization. Methods20 male Japanese big ears white rabbits are randomly devided into normal group (5), Zhennaoning capsule group (5), treatment group 1(5) and treatment group 2(5). First, one of the external carotid artery was higated and then we measured carotid-blood-flow (CBF) with electromagnetic-flow-meter recorded the changes of blood pressure. And electrocardiograph with physiologic instrument as well. In this experiment, the agent was feed by duodenum.25 male Japanese big ear white rabbits are randomly divided into five groups: normal group, Zhennaoning capsule group, treatment group 1 and treatment group 2. Every animal was feed with normal food and different agent accounting on the groups once a day. After three weeks, dextran-200 is injected through the edge-vein of the ear into every animal except the normal group. We observed the effects on blood viscosity; hemorrheology and platelet aggregation after the model has been made for 1 hour.Study the use of assuaging pain of through hot plate and spraining.Study the use of tranquilizing of CEHC on mice through shaking cage.Observe the incubation of relieving convulsions and death through peritoneal injection to study the use of relieving convulsion of CEHC on mice.Test the biggest tolerant multiple of CEHC. ResultsCEHC can increase the BBF and lower the BP. It didn't affect the blood pressure and heart rates.Blood viscosity, hemorrheology and platelet aggregation in the modal group increased rapidly, there was significant difference between the normal group and modal group (P<0. 01).Platelet aggregation, blood viscosity and hemorrheology are lower than those of the modal group. Compared with the treatment groups and the model group, there was great significant difference (P<0. 01).Compared the platelet aggregation, blood viscosity and...