| Objective To study the effects of phenobarbital (PB) monotherapy on immunofunctions in patients with epilepsy, the serum level of immunoglubulin IgA, IgG, IgM, and plasma PAF-AH were measured, and the effects of phenobarbital monotherapy on sex hormones and sexual functions were evaluated by measuring the serum concentrations of total testerone (TT), free esterone (FT), estradiol (E2), prolactin (PRL), luteinizing hormone (LH), follicle stimulating hormone (FSH) and investigating the scores of IIEF-5 in male patients with epilepsy.Methods Immune nephelometery was used to measure the serum level of immunoglubulin and ELISA was used to measure the plasma PAF-AH in patients with epilepsy who were treated with phenobarbital. Radioimmunoassay was used to measure the serum concentration of sex hormone and IIEF-5 investigating was used to estimate the sexual function in male patients with epilepsy who were treated with phenobarbital. Results Serum IgA level was significantly lower than that in normal matched group (p<0.01), IgG was higher in PB monotherapy group than that in normal matched group (p<0.05), no differences in serum IgM between PB monotherapy group and normal matched group (p>0.05); there is no correlation between the serum level of immunoglubulin and the course of epilepsy and the types of seizures. Plasma PAF-AH was higher in PB monotherapy group than that in the normal matched group (p<0.05) within 72h after the seizures of epilepsy, no differences between not-seizure group and normal matched group (p>0.05). Serum FT level was significantly lower than that in the normal matched group (p<0.05); no differences in serum TT, FSH, PRL, LH and E2 between PB monotherapy group and normal matched group (p>0.05). The scores of IIEF-5 were significantly lower than those in normal matched group (p<0.01), no differences between different course of epilepsy groups (p>0.05).Conclusion The phenobarbital monotherapy is effective, it has an effect on the serum... |
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