Red Ring Ningan, Clinical Efficacy And Mechanism Of Particle Treatment Of Iud Side Effects

Purpose: observing the clinical curative effect by taking Huan ning an chong pellet curing birth control implement by-reaction and screening the best useing medicine time.Flushes the pellet treatment birth control side reaction from pharmacodynamics experiment aspect to the action mechanism to conduct the research.Method:Study clinically:Adopt Pellet to cure the IUD by-reaction patient 90 examples,Divides into 3 groups stochastically, each group of 30 examples,Part for before menses rises 7th,Menses rises 3rd,See a doctor used medicine in that very day,Take one sack of pellet orally every time,3 times per day,2 Monday course of treatment,Use two course of treatment queens together,Determine patient blood plasma PGs value respectively.Pesticide effect learns to study:Uses the mouse to carry on the anti-inflammation experiment (the mouse auricle xylene sends the inflammation experiment and mouse abdominal cavity blood capillary permeability experiment)separately , Analgesia experiment(the acetic acid turns the body experiment), Hemoglutination experiment(the mouse eye socket vein draws blood experiment)and Resist bacteria experiment(resist bacteria experiment,bacteriostasis experiment,lowest bacteriostasis density experiment,lowest sterilization density experiment).Result:Study clinically:The premenstrual on 7th the group clinical cures 20 examples,appear imitating 4 examples,3 ineffective example,always have efficiency 90%; the group on 3rd cures 15 examples clinically,appear imitating 5 examples,5 ineffective examples,always have efficiency for 83.33%;13 examples seeing a doctor be recovered set clinically in that very day,appear imitating 6 examples,6 ineffective examples,always have efficiency for 80.00%.Among them,Use the medicine group on 7th and have notable difference other two set comparatively before menses rises(P<0.05).Three group of patients after treatment menstrual period remarkable reduction, after quantity reduction.The premenstrual on 7th the group the efficiency is higher than other two groups in the first treatment course with the second treatment course. On 7th the group is also most obvious in the symptom improvement aspect by the premenstrual, in which volume of menstrual flow many and leucorrhea exceptionally both are most remarkable, Improvement rate above 90%,The waist abdomen ache and the menstrual period lengthen the improvement rate is also high, above 80%. The revisit result premenstrual on 7th the group recurrence rate is lowest.The treatment future trouble blood plasma 6-K-PGF1αvalue obviously reduces, the TXB2 value obvious ascension, both ratio obviously reduces.Pesticide effect learns to study:Pellet can be caused by restraint dimethylbenzene small rat ear swelling composes in reply small rat abdominal cavity blood capillary permeability being caused by acetic acid increasing by.To being caused by acetic acid, twisting of the small rat experiences and observes a number also having fairly good inhibitory action.Can cut down a small rat obviously taking place curdling blood time.The bacteriostat experiment indicates inhibitory action to staphylococcus aureus , bacillus coli has equally。The resist bacteria experiment indicated link Ningan flushes the pellet has the bacteriostasis and the sterilization to the golden yellow staphylococcus and the backwoods coli, to copper vacation green Shan Baojun, the gonococcus and the white rosary fungus has not seen the obvious bacteriostasis function.Conclusion:Pellet may pass the contents adjusting prostaglandin's,And coordination it's the effect resisting imflammation , the blood time easing pain , restraining a bacterium and shortening out , curdling。Play treat role to the by-reaction that IUD arouses。Take curative effect best , the relapse rate minimum before menses rises on 7th.