Micron Rhubarb Charcoal Treatment Of Peptic Ulcer Bleeding Of Clinical Observation And Platelet Mechanism Of Action

Objective:Through observes under the gastroscope to spray the micron carbon Clinicalrhubarb to unify the method treatment digestion ulcer hemorrhage clinical curativeeffect which the entire journey takes medicine, and research clinical curative effectand thrombus element (TXA2), front row link element (PGI2) the relations, providefor the clinical practice this medicine treatment digestion ulcer follow the cardmedicine basis.Through series experimental study, to normal mouse hemoglutination time,hemorrhage time and platelet count influence; Gathers the function, TXA2, PGI2 aswell as the GMP-140 level influence to the normal big mouse blood platelet,confirmed the micron Chinese rhubarb coal really has stops bleeding the function,and possibly discusses its to stop bleeding the mechanism, for clinical provides thetheory basis with the medicine.Method:1. Stochastically divides into five groups 200 examples digestions ulcerhemorrhage patient, A: The micron Chinese rhubarb coal pure gastroscope sprays thegroup; B: The micron Chinese rhubarb coal entire journey gives the medicine group;C: Goes to the armor adrenalin pure gastroscope to spray the group; D: Goes to thearmor adrenalin entire journey to give the medicine group; E group for comparisongroup. Observes under the gastroscope the micron Chinese rhubarb coal group, goesto the armor adrenalin group patients instantly to stop bleeding the time, the bowelmovement transfers the cloudy time, the total effectiveness, not good responds aswell as in each group of patients blood plasma thrombus element TXA2, the PGI2content.2. Take the normal mouse as the experimental object, the observationmicron Chinese rhubarb coal to the mouse coagulation time, the bleeding time, theplatelet count influence 3. Take the normal big mouse as the experimental object, the observationmicron Chinese rhubarb coal gathers in the function, the blood plasma to the bloodplatelet TXA2, PGI2, the GMP-140 influence, the research micron Chinese rhubarbcoal to the blood platelet activation function function mechanism.Result:1. The clinical test indicated that, The micron Chinese rhubarb coal canobviously reduce the digestion ulcer to bleed the patient instantly to stop bleedingthe time, the curative effect surpasses the armor adrenalin (P＜0.01) After the micronChinese rhubarb coal group treats the bowel movement to transfer the cloudy time toreduce, the curative effect surpasses the comparison group (P＜0.05), Also notobviously not good responded that, the security is good. After the micron Chineserhubarb coal group and goes to on the armor the gland group to treat can cause thedrop the TXA2 value to elevate, causes the PGI2 drop which elevates, P＜0.05.2. Experimental study: Each treatment group may reduce mouse's hemorrhagetime, speeds up the hemoglutination time, the curative effect surpasses the Yunnanwhite medicinal powder group (P＜0.05). Micron Chinese rhubarb coal bigmonitoring team function is most obvious; Each group may increase platelet count,enhances blood platelet gathering rate, the micron Chinese rhubarb coal bigmonitoring team function is most obvious, the curative effect surpasses the Yunnanwhite medicinal powder group (P＜0.05). Each group may remarkably enhanceTXA2 to decline PGI2 the level, micron Chinese rhubarb coal big monitoring teamfunction is strongest, the curative effect surpasses the Yunnan white medicinalpowder group (P＜0.05). Each group can obviously raise big mouse GMP-140 thecontent, is remarkable with the comparison group comparison difference(P＜0.05or P＜0.01). Compares with the Yunnan white medicinal powder group does not have thedifference (P＞0.05).In short, The micron Chinese rhubarb coal treatment digestion ulcer hemorrhage isthe clinical treatment digestion ulcer hemorrhage one kind of security effectivetreatment medicine, its mechanism possibly through adjusts 6-keto-PGF1 alpha and between the TXB2 dynamical equilibrium, the acceleration blood platelet interiorpresses the congealing release, increase platelet count, enhances the blood plateletactiveness, the enhancement blood platelet adherency and gathers the function, thepromotion hemoglutination.