| Hyperlipemia is an independent risk factor of atherosclerosis and coronary heart disease . It has been confirmed that the reduction of lipid could improve endothelial function, suppress the progression of atherosclerosis, stabilize the plaque, reduce the morbility and mortality of acute coronary syndrome. Therefore, the effective reduction of lipid has been one of the main methods of preventing and treating cerebrovascular disease. Traditional Chinese Medicine is a unique theory system and has some special therapeutic effect on hyperlipidemia. This research take dispels symptoms such as dispersing the depressed liver-qi to promote blood flow, selects the traditional Chinese medicine to attach cyperi rhizoma, ligusticum wallichii, radices curcumae, semen persicae, safflower, radices paeoniae rubra, salvia miltiorrhiza bunge, fructus aurantii, ripe Chinese rhubarb, radix rehmanniae, platicodon grandiflorum, licorice to make the decoction.ObjectiveAppraises we to the hyperlipemia patient clinical symptoms improvement function, observes it to hyperlipemia patient blood serum TC, TG, LDL-C, the HDL-C level influence, as well as we security. Provides pharmacodynamics and the secure basis take the time as the clinical practice.Methods1 Clinical data : The 60 cases are selected from 2007.6-2008.1 outpatient and inpatient of Wuhan Hospital of Traditional Chinese medicine. They all accord with hyperlipemia's diagnosis standard, and the Chinese medicine syndrome is qi-stagnancy and blood stasis. Divides into the experimental group and the control group stochastically, each 30 cases, use parallel, the masculine comparison clinical trial method.2 Treatment project : The treatment group (30 cases) takes the traditional Chinese medicine decoction: cyperi rhizoma 10g, ligusticum wallichii 10g, radices curcumae 10g, semen persicae 10g, safflower 10g, radices paeoniae rubra 10g, Salvia miltiorrhiza bunge 10g, fructus aurantii 10g, ripe Chinese rhubarb 10g, radix rehmanniae 10g, platicodon grandiflorum 6g, licorice 6g, each medicinal preparation water will fry two times will take juice 150ml respectively, after the mix, altogether 300ml sooner or later to divide the clothing control group (30 cases) to take Atorvastatin calcium tablet (Beijing Jialin pharmaceutical industry limited liability company), 10mg/piece, each time 1 piece, daily 1 time, night will take orally. The treatment course is 4 weeks.3 Observation index : the curative effect of HLP, the symptoms' change of TCM and signs' of TC,TG,HDL,LDL, the blood-routine, the urine-routine, the stool-routine, electrocardiogram, liver function, kidney function.4 Statistical method : After four weeks, we analyze the data. The materials are examined with t-test, the count materials are examined with x~2 and the grade materials with Ridit.ResultTwo group of 60 cases patients complete the treatment, the compliance are good, has not appeared falls off, the rejection case.1 After four weeks, blood fats curative effect comparison : The treatment group falls the blood fats clinical inverse amplification factor is 16.67%, obviously the efficiency 33.33%, the total effectiveness is 76.67%, but the control group respectively is 23.33%, 40.00% and 86.67%, finally demonstrated that this formula has explicitly reduces the blood fats the function, compares the non-statistics difference with the control group (P>0.05).2 Different blood fats target comparison : Treatment group can reduce blood serum TC, TG, the LDL-C level effectively and elevates the HDL-C level. Only reducing the LDL-C horizontal aspect, is inferior to the control group.3 The effective of the TCM symptoms integral calculus : After two group of patient Chinese medicine card period of five days always grades the treatment, before treats, obviously reduces, demonstrated that two medicines have the distinct improvement function to the patient symptom. Group comparison, P<0.05, has the significance difference, explained that we reduce the patient symptom aspect to surpass the control group.4 Single item Chinese medicine symptom comparison : Single item card marquis integral comparison, after the treatment, before treats, obviously reduces, we can alleviate the chest to coerce the abdominal bloating effectively, walks flees the ache, before the heart the stabbing pain, annoyed restless, nearby the tip of tongue has the petechia either the ecchymosis, the weak pulse astringent and so on symptoms or the symptom.5 Safety analysis : Around the treatment group patients the common physical examination project changes not obviously, the blood, the urine, the bowel movement convention chemical examination, the electrocardiogram and the liver, the kidney function check has not seen the obvious change. Explanation treatment group medicine non-toxic side effect, safe reliable.ConclusionThrough this clinical trial, confirmed initially this formula uses in treating the hyperlipemia (the syndrome of qi-stagnancy and blood stasis) is one kind of security effective falls the fat medicine, has provided the reliable curative effect basis for the clinical practice. |
PDF Full Text Request