.218 Cases Of Breast Cancer After A Prospective Clinical Study Of Patients Certificate Distribution Law And Traditional Chinese Medicine To Alleviate The Endocrine Treatment Of Breast Cancer Clinical Adverse Reactions Observed

Research Purposes:To study the TCM syndrome classification of postoperative breast cancer cases and to observe the therapeutic effect of Chinese medicine alleviating adverse effects of endocrine therapy in postoperative breast cancerResearch Method:Analyze the information conveyed by 218 questionnaires based on therapeutic standards of this research.Observe syndrome distribution characteristic of postoperative breast patients, analyze the relationship between syndrome and disease stages,courses and estrogen and progesterone receptors.Compare and verify clinical coincidence rate of recent influential syndrome classifications. Meanwhile observe the syndrome scores change of 63 cases of adverse effects of endocrine therapy after TCM therapy.Research Results:â… .Syndromes distribution law of 218 casesFour hundred and two syndromes were obtained in 218 cases.There are 256 deficiency syndromes(63.68%) and 146 excessive syndromes (36.32%).Qi deficiency takes up the most percent of deficiency syndromes and then the Yin deficiency.And most of the excessive syndromes is Qi stagnation.â…¡.Syndromes distribution law of different disease stagesSyndromes of patients inâ… stage were chiefly Qi deficiency and Qi stagnation,â…¡stage Qi deficiency and Yin deficiency andâ…¢stage Qi deficiency,Yin deficiency and blood stasis.Qi deficiency tends to accumulate over stages while Qi stagnation and Blood deficiency tend to decline.Blood stasis and phlegm-damp syndrome inâ…¢stage is far more than that inâ… andâ…¡stages.â…¢.Syndromes distribution law of different disease coursesThe syndrome of post operation within one year was chiefly Qi deficiency,from 1^st to 3^rd year Yin deficiency,and from 3^rd to 5^th year Qi deficiency and Blood stasis.â…£.Syndromes distribution law of different estrogen and progesterone receptorsThe syndromes of 218 patients were chiefly Qi deficiency and Yin deficiency.Processed by statistics,Qi stagnation and Yin deficiency were mainly distributed in patients with ER+,Blood stasis and phlegm-damp in patients with ER-.But all these results were not valuable.â…¤.Syndrome types distribution law of 218 casesSyndromes of 218 cases totaled 402 and each case has on average 2 syndromes.Thirty-three syndrome types were obtained from 218 cases and 165 cases were the multiple syndrome types,which accounted for 75.69 percent.â…¥.Comparison between syndrome types classification standard of this paper and 3 current different classification standards.According to classification standard based on cluster analysis,307 of 402 syndromes(76.37%) were up to the standard.72 cases(33.03%) were up to the standard according to Professor Tang,69 cases(31.65%) to that of Breast Department of Guang Dong Province TCM Hospital.â…¦.Statistical analysis of Kuperman score change after TCM therapyThe syndrome scores of 63 cases were obviously lower that that before modified xiao yao san and er xian tang therapy,which illustrated the effective effect of that therapy on adverse effects of endocrine therapy,particularly on tidal fever and perspiration,temperament, fatigue,joint pain and palpitation.Conclusions:â… .Syndromes of postoperative breast cancer patients were multiple and complex,and mostly were deficient and excessive mixed syndrome.â…¡.Syndromes of postoperative breast cancer patients were mainly Qi deficiency and Yin deficiency,then Qi stagnation and Blood stasis.â…¢.Qi stagnation was more distributed inâ… stage or ER+ patients, which demonstrated a positive prognosis of patients with Qi Stagnation.â…£.Yin deficiency was more distributed in ER+ patients may correlated with endocrine therapy,which illustrated endocrine therapy can cause Yin deficiency.â…¤.The syndrome of post operation within one year was chiefly Qi deficiency,from 1^st to 3^rd year Yin deficiency,and from 3^rd to 5^th year Qi deficiency and Blood stasis.â…¥.The coincidence rates of syndrome classification standard of fixed model were low and the standards of fixed model were poorly manipulated.â…¦.The syndrome classification standard of this paper was based on singular syndrome and combining singular syndromes as a syndrome type,which can be applied to study the syndrome distribution characteristics of breast cancer patients.â…§.The curative effect of modified xiao yao san and er xian tang therapy on adverse effects of endocrine therapy was valid.