| Purpose:Objective evaluation of black beans compound ointment for treatment of hand eczema chapped efficacy and safety of Chinese medicine treatment of chapped hand eczema clinical studies provide a scientific basis for the development of eczema treatment of chapped hands lay the foundation for new drugs.Eczema is a common skin disease, the cause is more complex, and often closely related to allergy. At present the morphology of eczema as a name. The main clinical features of a variety of rash shaped lesions, exudation tendency to itching than the drama, often generalized or symmetrical, longer course, easy to persistent and chronic. Because of its increasing incidence and the incidence of people, causes and clinical symptoms are unique, being more and more attention of scholars, which chapped hands of the constant increase in the incidence of eczema, the incidence of occupational distribution is particularly evident to most women, in addition to industrial workers are often vulnerable to contracting this disease.In this study, black beans by observing the compound ointment for treatment of hand eczema chapped clinical symptoms, evaluation of black beans compound ointment for treatment of hand eczema chapped clinical efficacy and safety, to provide the basis for further improvement of traditional Chinese medicine formula, in order to better reduce the hand Department of chapped eczema symptoms, improve patients'quality of life.Method:Randomized controlled trials in this experiment, collected in April 2010 to March 2011 Xuzhou Hospital dermatology clinic chapped hand eczema patients. According to the inclusion and exclusion criteria, will meet the inclusion criteria of 80 patients divided into two groups, treatment group and the control of the 40 cases, the treatment group:treated with daily cleaning after hand black beans compound ointment in the evening after the applicator Pack 5 hours,1 time/day. Control group:treated with daily cleaning hands after urea Vitamin E ointment at night after the applicator Pack 5 hours,1 time/day. Asked two groups of patients according to medication, and asked the attention to the hand skin care, avoid contact with alkaline detergent and chemical drugs such as allergens. Referral once every 2 weeks,1 month for a course. detailed records of each lesion size, lesion morphology, and itching of adverse reactions after treatment, and after a month of its clinical efficacy and drug safety evaluation. All data applications SPSS15.0 statistical software for analysis.Results:Overall efficacy in the treatment group and control group. Treatment group the cure rate was 42.5%, total effective rate was 95%in the control group, the cure rate was 17.5%, total effective rate was 80%. Chi-square value 11.55, p= 0.009, P<0.05 overall efficacy of the two groups, the difference was significant. (P<0.05)Lesion area, the treatment group and control group. Treated lesions disappeared completely in 20%of patients, symptoms improved in patients with lesions of 75%, skin lesions disappeared completely in the control group 15%of patients, symptoms improved in patients with lesions was 46.2%. Chi-square value of 9.106, p= 0.028, P<0.05, two integrated effects, the difference was significant. (P<0.05)Itching of the treatment group and control group. Itching disappeared completely treated patients was 62.5%, itching to get control of the patients was 87.5%in the control group treated itching disappeared completely 30%of patients, itching to get control of the patients was 82.5%. Chi-square value 16.522, p= 0.001, P<0.05, two integrated effects, the difference was significant. (P<0.05)Treatment and control groups before and after treatment, clinical symptoms, lesion area, HESCI score, pruritus severity score, were decreased。... |
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