Synthesis And Anti-inflammatory Activity Evaluation Of Some Novel 3-amine-6-Alkoxy (Phenoxy)-[1,2,4] Triazolo [3,4,-α] Phthalazine Derivatives

Starting from phthalic anhydride, several new 3-amine-6-alkoxy(phenoxy)-[1,2,4]triazo-lo[3,4-a]phthalazine derivatives were synthesized as potent anti-inflammatory agent. Their anti-inflammatory activities were studied via the method of the xylene-induced ear edema in mice. The study showed that most of the synthsised compounds exhibited anti-inflammatory activity to a certain extent. Especially, the compounds 6h (3-amine-6-(2-chlorophenoxy)-[1,2, 4]triazolo[3,4-a]phthalazine) and 6s (3-amine6-(4-aminophenoxy)-[1,2,4]triazolo[3,4-a]phth-alazine) showed the highest anti-inflammatory activity (81% and 83% inhibition, respectively, at 0.5 h after i.p. administration) which were slightly more potent than the reference drug Ibuprofen (61%). Furthermore, the structure-activity relationship of these 1,2,4-triazole phthalazines was demonstrated.