The Study Of Urine Modified Nucleoside In Diagnosis And Correlation Of Biological Behaviors Of Bladder Transitional Cell Carcinoma

Background and objectiveBladde cancer is the most common urothelial tumors, including transitional cell carcinoma of bladder (BTCC) accounted for 94%, five years recurrence rate is as high as 50%～90% after first treatment, about 20% must be operated cystectomy eventually, the quality of life of the patients descend significantly. It is an urgent problem needed to solve about predicted recurrence effectively, early diagnosis and screening.Tumor marker in body fluids will help to find cancer in surver. However, most of tumor markers could not be well applied to survey and followed up cancer patients because of narrow detection scope and low sensitivity. As modified nucleosides reflect alter tRNA turnover which seems to be impaired in the body of cancer patients, they have been evaluated as potentoal tumor markers.We detected the levels of urinary modified nucleosides in bladder cancer group and control group, which was indicated by the ratio of nucleosides to creatinine and explore the feasibility of urinary modified nucleosides as potential molecular markers and its relation to biological behavior of bladder transitional cell carcinoma(BTCC).