The Effects Of Sufentanil On The Cardiovascular Response In Hypertension Geratics During The Induction Of General Anesthesia

Objective: To observes the effects of different dosage of Sufentanill in induced general anesthesia period on the hemodynamics and the blood plasma catecholamine in hypertension of geraticsMethods: Eighty ASAⅠorⅡhypertension geratics, age 65-75 years old, were randomized into four groups( n=20each), groupⅠ(fentanil 3ug/kg), groupⅡ(sufentanil: 0.2ug/kg), groupⅢ(sufentanil: 0.4ug/kg), groupⅣ(sufentanil: 0.6ug/kg), Separately records four group of patients to record SBP, DBP, MAP, HR before the induction T0, before the intubation T1, inserts a tube 1min T2,3min T3,5min T4, and records the above time extraction venous blood, unites the immunity adsorption law with the enzyme to measure the blood plasma catecholamine density the change.Results:①In T1 time, the groupⅢis lower than the basic value on SBP, DBP, MAP, but the decline rate is small and has statistics significance with other each group of differences, (P<0.05) In T2 time, the groupⅢonDBP, MAP restores to the baseline, but the groupⅠandgroupⅡalready surpassed the foundation value onDBP, MAP in this time interval, The groupⅣstill obviously was lower than the baseline, and has statistics significance with other each group of differences, (P<0.05) In T3 time,the SBP of groupⅢapproaches in the basic value, The groupⅠandⅡis higher than the baseline, The groupⅣstill obviously was lower than the baseline (P<0.05) But each group of DBP, MAP in this time difference non-statistics significance. In the T4 time, groupⅣSBP still obviously was lower than outside the baseline (P<0.05),Other each group of three targets approach in the baseline, and difference non-statistics significance.②. In T1 time, HR of groupⅣobviously is lower than outside the baseline, other each group and the baseline does not have the difference, but in T2~ T4 time interval, The groupⅠandⅡare higher than the baseline, The groupⅣin the time T2, T3 still obviously was lower than the baseline, restores in the T4 point in time to the basic value level. But the groupⅢtime interval and the foundation value does not have the difference in T2~ T4.③Blood plasma NE difference non-statistics significance, groupⅠwhen T4 the E density slightly has elevates(P<0.05) When T4 the groupⅢblood plasma E density is lower than F group (P<0.05) , four group of patient various points in time blood plasma NE density difference non-statistics significance.④The Fentanyl group patients realize the evanishment time ratio to extend Leader Fentanyl each (P<0.05)⑤Encircles the intubation time groupⅡandgroupⅠhas hypertension and the tachycardia the formation rate is higher than obviouslyⅢWithgroupⅣ, The groupⅣhypotension's formation rate is higher than obviouslyⅡWithgroupⅢ. blood plasma catecha phenol amine: With T0 when compares, four group of patient various points in timeConclusion: sufentanil 0.4ug/kg in the general anesthesia intubation period stress to respond that is small. And compares with 0.2ug/kg and 0.6ug/kg, 0.4ug/kg has the stabler blood stream dynamics .