| ObjectivesHypertension which is related to genetic factor and environmental factor is a common and frequently encountered disease in human beings, and the onset risk of coronary heart disease, diabetes mellitus, renal inadequacy and apoplexy is positively related to the situation of blood pressure. In order to emphasize the first-level protection of hypertension, JNC7 introduce a"prehypertension"in 2003, which is defined that systolic blood pressure (SBP) is between 120-139mmHg and (or) diastolic blood pressure (DBP) is between 80-89mmHg, meanwhile, advise to identify high-risk group efficiently among them and taking measures based on their own situation, like ordering their lifestyle, considering drug treatment, in order to step down the onset risk and cost price of anaphase cardiovascular disease. Now study show that the risk factors for prehypertension are smoking, age, fatness baseline BP and famili medical history. Uric acid and C-reactive protein (CRP) are taking people's reconstruction gradually as new type dangerous tumor marker. Hypertension is considered as a kind of chronic inflammation progressivity disease and CRP is the main inflammatory factor, study acquire that the increase of its blood serum level can indicate onset risk of hypertension independently. And some large scale clinical researches show that the level of blood uric acid is positively related to the onset risk of hypertension. In the study, we observe clinical express of blood uric acid and CRP in prehypertension group and discuss the relationship between them as well as its clinical significance in order to give some information on how to select high-risk group and give them direct intervention study.Methods176 patients were enrolled stochastically from patients who checked their health in affiliated Hospital of North China Medical College between June 2010 and July 2010. According to diagnostic code in JNC7, they were divided into 3 groups: normal group (<120/80mmHg) with 56 patients; prehypertension group (120-139mmHg /80-89mmHg) with 66 patients; hypertension group (SBP≥140mmHg/DBP≥90mmHg) with 54 patients. Take the data of their body height and weight, then the body mass index (BMI)was calculated, cuff type mercury column blood pressure gauge was used to measure their blood pressure. All the 3 groups were drawn 10ml blood sample in the second morning after fasting for 12 hours, the serum from sample was stored in -70℃refrigerator after centrifugation. The level of UA, total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDLC), low density lipoprotein cholesterol (LDLC), fasting blood glueose (FBG) and renal function were detect at one time with Bayer1650 type auto-biochemistry analysator which is from Siemens Co. in Germany, immunoturbidimetry was introduced in testing level of CRP, with kits produced by Japanese spinning Co.All data were put into the computer with the software of Excel and analyzed with the SPSS17.0 software. The measurement data were shown by (mean±SD), ANOVA was used in group comparison while Independent sample T check was used in in-group comparison; enumeration data was expressed by Pctig and checked by Chi-Square test; multiple linear regression was used in analysis the effection of UA and CRP for SBP, DBP; Pearson correlation analysis was used in analyzing the relevance between uric acid and CRP. A value of P<0.005 was considered as statistical significant. Results1. The value of TC, TG, LDLC, BMI and FBG in prehypertension group was absolutely higher than that in normal group(P<0.01)but lower than hypertension group(P<0.01); the value of HDLC in normal group was higher than that in prehypertension group and hypertension group(P<0.01).2. The value of uric acid and CRP in prehypertension group was 348.20±76.71umol/L and 1.94±0.39mg/L, absolutely higher than that in normal group(301.30±65.70umol/L, 1.34±0.37mg/L) (P<0.01), but lower than hypertension group(394.93±79.67umol/L, 2.56±0.64mg/L) (P<0.01).3. Multiple linear regression analysis showed that UA , CRP, FBG, BMI were correlated with SBP; and UA, TC, BMI, CRP were correlated with DBP(P<0.05).4. According to the uric acid, three groups were divided into 2 groups: normal uric acid group and the hyperuricemia group.The value of CRP (1.28±0.37, 1.61±0.23) was insignificanted in normal group (P>0.05), and there were significant differences in the value of CRP between the two groups in prehypertension group(1.81±0.37, 2.43±0.27) and hypertension group (2.25±0.58, 2.98±0.54)(P<0.05).5. According to the Pearson related analysis, the overall uric acid is positively related to the CRP(r=0.668,P<0.01); After grouping, the uric acid is not related to the CRP in normal group(r=0.232,P>0.05), but the uric acid is positively related to the CRP in the higher group and the lower group(r 0.681, 0.722, P<0.01), and this pertinence in the higher group is higher than that in the lower group.Conclusions1. UA, blood-fat, FBG, BMI and CRP had already changed in group of prehypertension, shown that there have abnormetabolisms and inflam- matory reaction in prehypertensions.2. UA and CRP were correlated with SBP and DBP.3.Tthere was correlation between UA and CRP. |
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