Research On The Treatment Of Irritable Bowel Syndrome With Constipation (Liver Depression And Spleen Deficiency Syndrome) By Si Ni San Reng Tang

PURPOSE1. Sini San Ren Tang observed treatment of constipation-predominant irritable bowel syndrome (liver spleen deficiency syndrome) and clinical efficacy.2. From both theoretical and clinical research systems analysis Sini San Ren Tang treatment of constipation-type IBS mechanism.METHODS1.Collection of information:60 patients, compliance with Western medicine and Chinese medicine, constipation IBS diagnostic criteria standard liver spleen deficiency, and all of Hubei Traditional Chinese Medicine Hospital from July 2009 to February 2011 gastroenterology specialist outpatient cases. Were randomly divided into two groups (treatment group and control group), two were 30.The treatment group ranged in age from 18 to 56 years, mean age 36.33±3.420 years slightly. The control group ranged in age from 21 to 60 years, mean age 37.53±3.718 years slightly. The statistical analysis of two groups of patients, their age, gender, disease duration, severity, symptom total score so there is no statistical significance (P> 0.05), comparable.2. Treatment:Treatment and control groups were given mosapride citrate tablet (brand name new network admittance) and compound Lactobacillus acidophilus tablets (brand name Yi Jun Kang) orally. On its basis, the treatment group with Sini San Ren Tang. Sini San Ren Tang is the mentor for many years of experience of Professor Hu party, (its composition as Bupleurum 10g, citrus aurantium 10g, white peony root 10 g, Glycyrrhizae 6 g, almonds 10g, Coix seed 10g, Bai Kou Ren 10g, woody 12 g, Magnolia 10g, Bai Zhu 20g, Chinese yam 30g), these drugs Shuijianbi day one, sooner or later, the 1st half an hour after a meal, each 200ml; new network is satisfied orally,3 times a day, every time 100mg, taken before meals; Yi Jun Kang orally, three times a day 2 (1g) tablets after meals. All patients a course of continuous medication (weeks), and were given safety observation (such as general physical examination items, the three routine inspections; liver and kidney function; electrocardiogram; possible adverse reactions) and efficacy of the observation (abdominal pain or bloating stool and the corresponding clinical signs and symptoms, clinical total score changes before and after treatment).3. After the treatment, its statistical analysis to determine its efficacy.Statistics by SPSS13.0 statistical software:Inspection by Ridit level data, count data with the X2 test, measurement data using t test. RESULTS1.Comprehensive clinical efficacy:treatment group:5 patients recovered,16 cases markedly effective in 6 cases,3 cases, total effective rate 90.00%. Control group:2 patients cured,7 cases markedly effective in 9 cases,12 cases,60.00% total efficiency. The two groups, treatment group, the cure rate and total effective rate higher (P<0.05).2. Two groups of patients after treatment of clinical symptoms before and after treatment total score were significantly different (P<0.05), total score of clinical symptoms improved, the treatment group more than the control group (P<0.05).Can significantly improve the treatment group, abdominal pain, bloating, dry stool, depression and other symptoms, and excellent than the control group; counterparts bitter, early satiety, belching, bowel control group effort and a considerable improvement.3. Sini San Ren Tang treatment of constipation-predominant irritable bowel syndrome have a significantly alleviate clinical symptoms, non-toxic side effects, affordable, can be promoted.CONCLUSIONThis clinical study shows Integrative Medicine constipation-predominant irritable bowel syndrome (liver spleen deficiency syndrome) was better than western medicine, with good clinical efficacy. Theoretical analysis of the modern pharmacological studies, Sini San Ren Tang may have two-way regulating gastrointestinal function. Promote gastrointestinal motility and secretion, relieve intestinal smooth muscle spasm, pain spasm, soften fecal matter, and other functions to promote stool, combined with western medicine can be related to synergistic effects. Description Sini San Ren Tang clinical practice to meet the group side, in the treatment of IBS-C (liver spleen deficiency syndrome) that had a certain effect, it is application and promotion.