Study On Infectious And Risk Factors Of HCV In The Entry-exit People Of Kunshan District

Objective:To analysis the level of Hepatitis C(HCV)infection and the infectivity and risk factors of HCV infection in entry-exit people of KunShan district, and provide the specific control measures of HCV condition progress to reduce the infectious risk to protect health of entry-exit people of KunShan district.Methods:Enzyme-linked immunosorbent assay (ELISA) screening is used for testing hepatitis C virus antibodies (anti-HCV) in entry-exit people of KunShan district. Real-time fluorescent quantitative PCR method is used for the determination of 150 cases of positive anti-HCV RNA in Sera of viral load. 1:4 matched case—control study was conducted.The objective with same sex, age (±3), anti-HCV negative were recruited as matched controls. Single and multivariate conditional Logistic regression was conducted to analysis the differences between the anti-HCV positive group and negative control group.Results:150 anti-HCV positive were detected from 23781 entry-exit peoples of KunShan district through the health examination of Communicable Disease Surveillance. Detection rate was 0.63%, lower than the infection lever of Chinese peoples(3.2%). Man and women have the equal chance of HCV infection(χ~2=0.506,P>0.05). Anti-HCV-positive rate increased with age(χ~2=86.065,P<0.001). Anti-HCV positive rate of foreign crowd was significantly lower than populations in China and Hong Kong, Macao, Taiwan(χ~2=12.376,P<0.05). HCVRNA virus is in replication status among 78.67% Anti-HCV-positive people. Viral load of HCVRNA was≤500copy/ml among those people with anti-HCV titer≤1:16. Viral load of HCVRNA was≥1.02 X 10~4copy/ml among those people with anti-HCV titer≥1:64. Viral load of HCVRNA was significantly different among people with various levels of antibody titers(χ~2=136.593,P<0.001). According to the result of single conditional logistic regression nationality, ALT, AST, DBIL, BU, CHOL and LDL were the risk factors of HCV. However, multivariate conditional Logistic regression model dose not have statistical significance.Conclusion:78.67% HCV infection of entry-exit people of Kunshan district were infectious. Anti-HCV titer≥1: 64 can be regard as the judgment index for HCV infection. Nationality, ALT, AST, DBIL, BU, CHOL and LDL were the risk factors of HCV.