Comparison Of Effects Of Oral Celecoxib,Oxycodone/Acetaminophen And Gabapentin On Postoperative Pain In Laparoscopic Surgery

Objective To investigate the postoperative analgesia effects of oral administration of celecoxib, oxycodone/acetaminophen and gabapentin on patients with laparoscopic cholecystectomy.Methods Sixty patients undergoing laparoscopic cholecystectomy were randomly divided into three groups:celecoxib group(group A), oxycodone/acetaminophen group(group B) and gabapentin group(group c),20 cases in each. The medicines were given at the time of 8 hours before surgery and 6 hours after operation (patients can eat), patients continued to eat medicines until the third postoperative day. Patients in group A were given two capsules of celecoxib (200mg/each capsule) 8 hours prior to surgery, and then one capsule was taken at the time of 6 hours after operation. Celecoxib was administered 1 capsule twice a day(in the morning and evening) at the following two days. Patients in group B were given one tablet of oxycodone/acetaminophen (5mg acetaminophen and 325mg oxycodone in each tablet) 8 hours prior to surgery, and then one tablet was taken at the time of 6 hours after operation. Oxycodone/acetaminophen was administered 1 tablet twice a day(in the morning, noon and evening) at the following two days. Patients in group C were given three capsules of gabapentin (300mg/each capsule) 8 hours prior to surgery, and then one capsule was taken at the time of 6 hours after operation when patients could eat, gabapentin was administered 1 capsule thrice a day(in the morning, noon and evening) in the first and the second surgery day. The visual analogue scale (VAS) at rest and in moving, Ramsay scores and the side effects were observed and recorded at the time of 30min after waking up,6 hours,12 hours,24 hours and 48 hours after surgery.Results No significant difference was found in VAS at rest between the three groups (P>0.05). VAS in moving at 6h、12h、24 h after the surgery was significantly different among the groups (P<0.05), in which VAS in group C was the highest, second was in group A, the lowest was in group B. There was a significant difference in Ramsay scores at 0.5h、6 h、12 h、24 h after surgery among the groups (P<0.05). Ramsay score in group C was the highest, second was in group B, the lowest was in group A. There was no significant difference in the side effects among the groups (P>0.05).Conclusion All the methods of oral administration of celecoxib, oxycodone/acetaminophen and gabapentin are effective in perioperative analgesia after laparoscopic cholecystectomy. The analgesic effect of oxycodone/acetaminophen is the strongest. The sedative effect of gabapentin is the best.