Retinal Nerve Fiber Layer In Primary Open-angle Glaucoma With High Myopia Determined By Optical Coherence Tomography And Scanning Laser Polarimetry With Variable Corneal Compensation

ObjectiveTo determine the characteristics of the Retinal nerve fiber layer (RNFL) thickness in Primary open-angle glaucoma(POAG) with high myopia (HM) and to evaluate the diagnostic efficiency of the Optical coherence tomography (OCT) and scanning laser polarimetry with variable corneal compensation (GDxVCC).MethodsGDxVCC, OCT were used to detect the RNFL thickness from12cases(12eyes) of POAG complicated with HM with spherical equivalent refraction (SE)-6.0D～-12.0D.12cases (12eyes) of HM with spherical equivalent refraction(SE)-6.0D～-12.0D were served as control. Automated Perimetry were also used to detect visual field defects in both groups. OCT parameters including the Superior Average(Savg), Inferior average (Iavg), Nasal average (Navg).Temporal average (Tavg), Average Thickness(Avg.Thick). The OCT parameters were obtained with the Fast RNFL thickness scanning. GDxVCC parameters including Superior Average, Inferior Average, TSNIT Average, Nerve Fiber Indicator (NFI). Automated Perimetry parameters including mean defect (MD), pattern standard deviation (PSD). Statistical Procedures for the Social Sciences (SPSS for Windows16.0) was used for descriptive statistics and data analysis.ResultsThere was no significant difference regarding age and SE between HM and HM with POAG groups (P>0.05). Superior Average, Inferior Average, TSNIT Average, Savg, Iavg, Tavg, and Avg.Thick significantly decreased and NFI significantly increased in HM with POAG group compared with those in HM group (P<0.05), whereas Navg had no significant difference between two groups (P>0.05). A significant association was found between TSNIT Average and Avg.Thick, TSNIT Average and MD, Avg.Thick and MD, TSNIT Average and PSD, Avg.Thick and PSD (r=0.764,0.727,0.637,-0.735,-0.774respectively, P<0.05). The Area Under Receiver Operating Characteristic Curve (AUROC) of Superior Average, Inferior Average, TSNIT Average, NFI, Savg, Iavg, Navg, Tavg, Avg.Thick were0.972,0.882,0.958,0.993,0.896,0.927,0.576,0.958,0.965, respectively. The AUROC of NFI was the maximum value.Conclusion1.RNFL thickness significantly decreased in POAG with HM patients compared to HM patients regarding Superior Average, Inferior Average, TSNIT Average, Savg, Iavg, Tavg, Avg.Thick, whose parameters derived from OCT and GDxVCC, whereas Navg is not significantly different.2. OCT and GDxVCC are well correlated in detecting the RNFL thickness for POAG with HM patients and HM patients.3. OCT and GDxVCC both have good diagnostic power of POAG with HM. GDxVCC is better in the diagnosis of POAG with HM than OCT. Diagnostic power: NFI> Superior Average> Avg.Thick> TSNIT Average、Tavg> Iavg> Savg>Inferior Average> Navg. Navg is less effective.