The Research Of Psychological Stress And Diminished Ovarian Reserve

ObjectivesDiminished Ovarian Reserve includ physiological DOR related of age and non physiological DOR not related of age. The reasons cause DOR are more complex, Clinical studies have emotional stimuli to early menopause cases, this show that psychological stress and DOR have certain relationship, and our group have collected48cases DOR patients in2009-2010, through the life Events Scale found that85%of the patients who have family or life work to major events occurred or existence of the long term mental pressure,These studies confirm psychological stress should be one of the important reasons for the DOR,so further research is necessary for psychological stress and DOR. This study is designed to investigate patients with Diminished Ovarian Reserve and healthy women through questionnaire survey, to analy the present situation of psychological stress, to explore the difference of ovarian function,It can provide correlation basis between the two for clinical. On the other hand analysis DOR traditional Chinese medical(TCM) syndrome, in order to provide basis for clinical.MethodsWe choose the patients with diminished ovarian reserve and heathy women with normal ovarian reserve.We have to test there ovarian function, and to investigate the patients with questionnaire of Residents General Status Table, psychological social stress survey for Groups (PSSG), self-ratingdepression scale (SDS), self-ratinganxiety scale (SAS), TCM syndrome from the four diagnostic information collection table, analyzed statistically by spss13.0statistical analysis software.Result 1. The patients with diminished ovarian reserve and healthy women with normal ovarian reserve have statistically significant differences in the cultural level, marital status, occupation, birth requirement (P<0.05).The multiple covariance analysis control base level difference, to compare both psychological stress situation, the results show that two groups have statistically significant differences in life events (L), negative emotion (NE), negative coping style (NC),total stress score, total SAS score(P<0.05).2. The result of univariate logistic regression analysis show that life events (L), negative emotion (NE), negative coping style (NC),total stress score, total SAS score(P<0.05), family feud or marital problems, interpersonal relationship not harmonious fear, distress, depression, anger, anxiety, worry, helpless, easy to get into memory and fantasies can’t get rid of, shoot the others and often lose his temper, like will of his emotions pressure in the bottom of my heart, do not let its expression comes out, but also not forget, for no untoward, usually thinking hard contradictions, These factors are related with diminished ovarian reserve (P<0.05, OR>1)3. The resut of binary logistic regression analysis show that negative emotion (P<0.05,OR=2.08)、total SAS score (P<0.05, OR=1.12) are factors of diminished ovarian reserve.4. The clinical maifestation of DOR:irregular menstruation, yellow complexion, Facial dark spots, the dark red color, with blood clot, shenpi fatigue, irritable, upset many dreams, chills limb cold, gas less lazy to talk, dry mouth, mouth bitter,lumbar debility, tongue reddish, moss white, pulse heavy fine and so on.5. The main irregular menstruation of DOR patients is menstruation (21.9%) and hypomenorrhea (50%)6. The mainly of DOR of TCM syndrome manifestations are Kidney Liver Depression(46.9%), Spleen Liver Depression(18.8%), Kidney Deficiency(15.6%).Conclusion1. The life events (L), negative emotion (NE), negative coping style (NC) of psychological stress factors are related to DOR, total negative emotions and anxiety from review scores on the high side of women who increased risk of DOR.2. The mainly of DOR of TCM syndrome manifestations are Kidney Liver Depression, Spleen Liver Depression, Kidney Deficiency.