Determination Of Serum CA72-4, CA125, CA199, CEA Level In The Diagnosis Of Gastric Cancer, Colorectal, Gastirc Stromal Tumors Is Explored

Because of the pollution of the environment, the aging of the population,genetic factors, lack of exercise and other bad habits lead to the increasingnumber of cancer. Who is expected to2020the whole world cancer incidencethan is now increased to50%, which was an important part of digestive tracttumor. China’s digestive tract tumor incidence rates are on the rise, the fatalityrate in cancer ranks first in. At the same time, as in recent years thedevelopment of medical technology, the means of diagnosis and treatment ofgastrointestinal tumor also change rapidly, new diagnostic, therapeutic methodsemerge in an endless stream, commonly used diagnostic method forpathological examination, imaging examination, endoscopy, serum biochemicalindex test.The serum tumor markers for detection of clinically as the mostconvenient common detection method, has been widely used in clinical tumordiagnosis, curative effect observation and judgment of prognosis andmonitoring of disease. However, at present as a tumor marker tumor antigensare nonspecific antigen detection, single index, sensitivity is low, there is a bigrate of misdiagnosis, specificity is poor, need the help of other auxiliarydiagnosis, therefore in the screening and early diagnosis of tumors have certainlimitations. Therefore, the combined detection of tumor markers for the clinicaldiagnosis is very important, at the same time can improve the diagnosis ofcombined detection of tumor sensitivity and specificity to a certain extent so asto compensate for the individual to detect defects, similarly to the digestivetract tumor early diagnosis and postoperative surveillance of patients has important value.To find tumor-specific antigen has been the hot spots of cancer research,and serum tumor markers in the early days of high hopes, hopes that it will playan important role in the diagnosis and treatment of tumors.CA72-4as a gastrointestinal tumor markers for gastric, colorectal cancer,there is a high degree of specificity,85%~95%of the stomach, colon cancerpatients can detect CA72-4elevated, benign tumor, exudate or normal tissuedetect CA72-4. According to reports confirmed, CA72-4in gastrointestinaltumor sensitivity to78.8%for diagnosis of gastric cancer, colorectal cancer, is areliable marker. CA125antigen by OC125antibody recognition. This antigen ina variety of tumors, such as breast cancer, gastric cancer, liver cancer,pancreatic cancer, colon cancer, lung cancer, endometrial cancer and othertumors of different degrees of expression. In fetal amniotic membrane and fromcoelomic epithelium derived tissues, as well as in the adult oviductal epitheliumof the endometrium and cervix, endometrium can be found in the CA125antigen. Serum CA125concentrations in some benign diseases also will beimproved, such as the number of benign gynecological diseases, earlypregnancy, acute or chronic pancreatitis, chronic hepatitis, non malignantgastrointestinal diseases, malignant tumors of digestive tract, renalinsufficiency, autoimmune disease. Thus, CA125lower specificity. CA19-9alsoknown as gastric cancer associated antigen CA19-9, also known asgastrointestinal tumor associated antigen, is a kind of adenocarcinoma of theantigenic substance, in cancer cells, via the thoracic duct drainage into theblood circulation, so that the CA19-9levels in peripheral blood in elevation, thehighest content in the digestive tract of. When the gastric colorectal cancer withliver metastasis when CA19-9increased significantly, higher than that of othertumor markers. CA199diagnosis of malignant tumor of digestive system issuperior to other tumor markers. CEA as the most common tumor markers, are widely used in all kinds of digestive system tumor diagnosis and monitoring.CEA is from colon and embryonic tissues extracted a tumor-associated antigen,it belongs to the tumor cell surface antigens in the cytoplasm of the structure,form, through the cell membrane into the surrounding body fluids, can be in avariety of body fluid detection.This research selected646cases of gastric cancer, which group of214cases,354cases of colorectal cancer, gastric stromal tumor in25cases,53casesof the control group. Discussion on the application of serum tumor markers,and through the analysis of serum tumor markers in gastric and colorectalcancer patients in level, the detecting results are statistically processed, exploreits in the diagnosis of gastric cancer, colorectal cancer and gastric prognosis incolorectal cancer patients application.