Clinical Significance Of Serum CEA, CA125 And CA72-4 In Gastric Carcinoma With Peritoneal Metastasis

Objective:To investigate the diagnostic value and clinical significance of CEA,CA125 and CA72-4 in gastric carcinoma patients with peritoneal metastasis.Methods:108 gastric carcinoma with peritoneal metastasis patients from January 2008 to December 2013 were studied.All patients were diagnosed by imaging,operations and pathlogical examination,and also received intravenous or intraperitoneal chemotherapy.Serum tumor markers CEA,CA125 and CA72-4 were determined during diagnosis and before each chemotherapy.The diagnostic sensitivity of single and combine with two or three markers were analyzed.The correlations among the serum tumor markers and clinicopathological factors,chemotherapeutic effects and survival time were analyzed.Results:Positive rates of CEA,CA125 and CA72-4 were 20.4%,46.3%and 45.4%in gastric cancer patients with peritoneal metastasis,respectively.For these patients,the positive rates of combine detected CEA/CA125,CEA/CA72-4,CA125/CA72-4 and CEA/CA125/CA72-4 were 54.7%,52.8%,69.5%and 79.6%,respectively.The combine detection of 3 tumor markers was much better than unitary detection(P<0.05).Positive rates of CEA,CA125 and CA72-4 were correlated with the ECOG scale(P<0.05).Positive rate of CA125 was associated with ascites(P<0.001))while positive rate of CA72-4 was associated with ovarian metastasis(P<0.05).Median survival time of patients with positive rate of CEA,CA125 and CA724 were significant lower than that the patients with normal levels of these markers(P<0.05).Compared with pre-treatment,the levels of all three tumor markers were significantly declined after three cycles of chemotherapy(P<0.05).The CA125 declined after chemotherapy was significantly correlated with the amount of ascites decreased(P<0.05).The tumor markers turned negative after three cycles chemotherapy in patients with positive of initial diagnosis,their survival period was significant prolonged(P<0.001).Conclusion:Combined detection of serum CEA,CA125 and CA72-4 can significantly promote diagnostic rate of gastric cancer with peritoneal metastasis,and can evaluate chemotherapeutic effects and predict prognosis.